Abstract
Purpose
Pseudoexfoliation (PEX) syndrome is an age-related disease characterized by the accumulation of extracellular material in many ocular structures, skin and internal organs. Recent studies have shown that the Triglyceride-Glucose (TyG) index has clinical importance for the evaluation of vascular damage. The purpose of this study was to determine the relationship between PEX syndrome and TyG index, and to detect the risk in terms of vascular diseases.
Methods
In the present study, 50 patients with PEX syndrome who were admitted to the ophthalmology outpatient clinic were evaluated along with 50 others who made up the control group. The Triglyceride-Glucose index was calculated with fasting plasma glucose and triglyceride values.
Results
The mean age was 68.2 ± 1.2 years and 61.0% of the patients were male. There was no statistically significant difference between the two groups in terms of blood sugar and lipid profile (except triglyceride) (p > 0.05). The TyG index value was 8.9 ± 0.5 in the PEX group and 8.6 ± 0.6 in the control group. This difference was statistically significant (p = 0.003). In univariate regression analysis, TyG index (OR = 2.81; CI: 1.37–5.75; p = 0.005) was found to be correlated with PEX. In multivariate logistic regression analysis, this correlation remained statistically significant when adjusted for age and sex (OR = 2.89; CI: 1.35–6.18; p = 0.006).
Conclusion
Results showed that the TyG index was high in patients diagnosed with PEX. The risk of vascular diseases can be determined by examining the TyG index in patients with PEX, and this predetermination would have significant consequences for public health.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the (Clinical Research Ethics Committee of Kırşehir AhiEvran University Faculty of Medicine (No: 2021–13/147) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Abay, R.N., Katipoğlu, Z. The correlation between pseudoexfoliation syndrome and the Triglyceride-Glucose index. Graefes Arch Clin Exp Ophthalmol 260, 3903–3908 (2022). https://doi.org/10.1007/s00417-022-05737-z
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DOI: https://doi.org/10.1007/s00417-022-05737-z