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Predicting retinal sensitivity using optical coherence tomography parameters in central serous chorioretinopathy

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To predict changes in retinal sensitivity using optical coherence tomography (OCT) in eyes with central serous chorioretinopathy (CSC).

Methods

Twenty-three eyes in 23 patients with CSC were enrolled. Retinal sensitivity was measured twice using microperimetry in all the examined eyes. Spectral domain OCT measurements were simultaneously conducted. The relationship between retinal sensitivity and the thicknesses of (i) the retinal nerve fiber layer plus the ganglion cell layer (RNFL + GCL), (ii) the inner nuclear layer (INL), (iii) the outer nuclear layer (ONL), and (iv) the serous retinal detachment height (SRDH) were investigated in a point-wise manner. The associations between the change in retinal sensitivity and the OCT parameters at baseline were also investigated.

Results

The mean age of the participants was 49.8 ± 10.7 years. The mean SRDH was significantly lower (p < 0.001), and the mean retinal sensitivity (p < 0.001) was significantly higher at the second examination, compared with the first; however, the logMAR visual acuity (VA) did not differ significantly between the two examinations (p = 0.063). The logMAR VA was associated with retinal sensitivity at both the first and second examinations (p < 0.001). The retinal sensitivity at the second examination was significantly correlated with the retinal sensitivity, RNFL + GCL, INL, ONL, and SRDH at the first examination and with the improvement in SRDH.

Conclusions

Retinal sensitivity was associated with the retinal structure in eyes with CSC; these parameters could be useful for predicting the change in visual function prior to treatment.

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Author information

Authors and Affiliations

  1. Saitama Red Cross Hospital, 1-5 Shintoshin, Chuo-ku, Saitama-shi, Saitama, Japan

    Satoru Kanda

  2. Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Satoru Kanda, Han Peng Zhou, Ryosuke Fujino, Aya Sugiura, Yurika Aoyama, Ryo Obata & Ryo Asaoka

  3. Department of Ophthalmology and Micro-Technology, Yokohama City University, 4-57 Urafune, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan

    Tatsuya Inoue, Kazuaki Kadonosono & Maiko Maruyama-Inoue

Authors
  1. Satoru Kanda
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  2. Han Peng Zhou
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  3. Tatsuya Inoue
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  4. Ryosuke Fujino
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  5. Aya Sugiura
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  6. Yurika Aoyama
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  7. Kazuaki Kadonosono
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  8. Maiko Maruyama-Inoue
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  9. Ryo Obata
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  10. Ryo Asaoka
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Contributions

SK and TI were responsible for writing the protocol and report, conducting the search, screening potentially eligible studies, extracting and analyzing data, interpreting results, updating reference lists and creating the “Summary of findings” tables. HZ, RF, AS, YA, KK, MM, RO, and RA provided feedback on the report. All the authors have read and approved the manuscript.

Corresponding authors

Correspondence to Tatsuya Inoue or Ryo Asaoka.

Ethics declarations

Ethics approval and consent to participate

This study was approved by the Research Ethics Committee of the Graduate School of Medicine and Faculty of Medicine at The University of Tokyo. The committee’s reference number is 2217.

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Competing interests

The authors declare no competing interests.

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Kanda, S., Zhou, H.P., Inoue, T. et al. Predicting retinal sensitivity using optical coherence tomography parameters in central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 260, 3499–3504 (2022). https://doi.org/10.1007/s00417-022-05717-3

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  • DOI: https://doi.org/10.1007/s00417-022-05717-3

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