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Optical coherence tomography angiography quantification of choriocapillaris blood-flow after half-fluence photodynamic therapy for chronic central serous chorioretinopathy

  • Retinal Disorders
  • Published:
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A Correction to this article was published on 30 April 2022

This article has been updated

Abstract

Purpose

To quantitatively analyze characteristics of choriocapillaris flow using spectral domain optical coherence tomography angiography (SD-OCTA) in eyes with chronic central serous chorioretinopathy (CSC) before and after treatment by photodynamic therapy (PDT).

Methods

Retrospective interventional study. Macular 3X3 SD-OCT scans were analyzed in eyes diagnosed with chronic CSC before and after treatment with half-fluence PDT. The choriocapillaris en face slabs were extracted from the SD-OCTA device after manual segmentation. En face choriocapillaris flow images were compensated with en face choriocapillaris structure images. Phansalkar local thresholding method was then used with a radius of 4 and 8 pixels. Percentage of flow deficits (FD%), number, size, and total area of FDs were computed for comparison, before and after treatment by half-fluence PDT.

Results

Mean choriocapillaris FD% before PDT was of 58.36 + / − 11.88 and of 60.82 + / − 11.08 after PDT using radius 4 pixels with no significant difference (p = 0.140). Mean choriocapillaris FD% was of 58.63 + / − 11.08 before PDT and of 60.87 + / − 10.36 after PDT using radius 8 pixels with no significant difference (p = 0.200). Similarly, no significative difference was found in number, size, and total area of FDs, before and after half-fluence PDT, using radius 4 and 8 pixels in patients with chronic CSC.

Conclusion

Using Phansalkar local thresholding method, quantitative analysis of choriocapillaris with SD-OCTA found no significant change in choriocapillaris flow deficits before and after successful half-fluence PDT in patients with chronic CSC. Therefore, it seems that half-fluence PDT may not alter choriocapillaris perfusion, at least on a relative short-term basis.

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Funding

This study is supported by an unrestricted grant from CIL-ASSOC (Paris, France), an association for research and education. The funding organization had no role in the design or conduct of this research.

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Authors and Affiliations

  1. Department of Ophthalmology, Intercity Hospital, University Paris Est Créteil, Créteil, France

    Hoang Mai Le & Salomon Y. Cohen

  2. Ophthalmic Center for Imagery and Laser, Paris, France

    Sarah Mrejen, Lise Sibilia & Salomon Y. Cohen

Authors
  1. Hoang Mai Le
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  2. Sarah Mrejen
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  3. Lise Sibilia
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  4. Salomon Y. Cohen
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Contributions

Conceptualization: Salomon Y Cohen; Methodology: HoangMai Le, Salomon Y Cohen, Sarah Mrejen; Formal analysis and investigation: HoangMai Le, Lise Sibilia; Writing—original draft preparation: HoangMai Le; Writing—review and editing: Salomon Y Cohen, Sarah Mrejen; Funding acquisition: Salomon Y Cohen.

Corresponding author

Correspondence to Salomon Y. Cohen.

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Ethics approval

Approval was given by the Independent Review Board/Ethical Committee of the Federation France Macula.

Consent to participate

Not applicable (retrospective study).

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Not applicable (retrospective study).

Conflict of interest

Dr Le and Mrs Sibilia have no financial interest to declare. Dr Mrejen is consultant for Bayer and Novartis. Dr Cohen is consultant for Allergan, Bayer, Novartis, Roche, and Thea.

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The original version of this article was revised. Figure 1 is now corrected.

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Le, H.M., Mrejen, S., Sibilia, L. et al. Optical coherence tomography angiography quantification of choriocapillaris blood-flow after half-fluence photodynamic therapy for chronic central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 260, 2483–2490 (2022). https://doi.org/10.1007/s00417-022-05637-2

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  • DOI: https://doi.org/10.1007/s00417-022-05637-2

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