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Regression patterns of central serous chorioretinopathy using en face optical coherence tomography

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To study the regression patterns of subretinal fluid (SRF) in central serous chorioretinopathy (CSCR) on sequential en face optical coherence tomography (OCT) and its relationship to leak locations.

Methods

Retrospective study on patients with acute CSCR. Inclusion criteria were (i) availability of data, sequential OCT and OCT angiography (B scan and en face OCT) every 2 weeks until resolution of SRF or 6 months, whichever is earlier; (ii) single active leak. Exclusion criteria were (i) presence of macular neovascularization or atypical CSCR, (ii) diffuse pigment epitheliopathy, (iii) multiple leaks. Serial en face OCT scans were evaluated and the area of SRF was measured using ImageJ software. Correlation coefficient was calculated for the regression rate of SRF area and central retinal thickness (CRT) over the first month of follow-up and the time of complete SRF resolution.

Results

Out of the 25 eyes, 20 eyes demonstrated a centripetal regression, and 5 eyes demonstrated a centrifugal regression. In eyes with a leakage point <1000μ from the fovea, 86% resolved in a centripetal fashion, and in eyes with leak site ≥1000μ away from fovea, 70% eyes resolved centripetally. There was a correlation (r=−0.47, p=0.018) of the rate regression of SRF area during the first month and timing of resolution. In contrast, this correlation was absent (r=−0.16, p=0.44) for CRT regression.

Conclusion

Our en face–based analysis of sequential OCTs of regressing CSCR demonstrated a tendency for the subfoveal SRF to resolve towards the end or a centripetal pattern of regression. Prediction of resolution of SRF at 1 month is better with en face area of SRF in comparison to CRT.

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Data availability

Available upon request.

Code availability

Not applicable.

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Central Serous Chorioretinopathy Study Group:

Supriya Arora (Eye Care Center, Princess Margaret Hospital, Nassau NP, Bahamas); Brian Rosario (UPMC Eye Center, University of Pittsburgh, Pittsburgh); Abdul Rasheed Mohammed (School of Optometry and Vision Science, University of Waterloo, Canada); Oliver Beale (UPMC Eye Center, University of Pittsburgh, Pittsburgh); Sumit Randhir Singh (Nilima Sinha Medical College & Hospital, Rampur, Madhepura, Bihar 852113, India); Amrish Selvam (UPMC Eye Center, University of Pittsburgh, Pittsburgh); Gunjan Chhablani (Department of Computer Science, BITS Pilani, Birla Goa Campus, Goa, India); Ramesh Venkatesh (Department of Retina and Vitreous, Narayana Nethralaya, Bengaluru, India); Nikitha Reddy (Department of Retina and Vitreous, Narayana Nethralaya, Bengaluru, India); Alexei N. Kulikov (Department of Ophthalmology, Military Medical Academy, St. Petersburg, Russian Federation); Dmitrii S. Maltsev (Department of Ophthalmology, Military Medical Academy, St. Petersburg, Russian Federation)

Jay Chhablani (UPMC Eye Center, University of Pittsburgh, Pittsburgh)

Author information

Authors and Affiliations

  1. Bahamas Vision Centre and Princess Margaret Hospital, Nassau NP, Bahamas

    Supriya Arora

  2. UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA, USA

    Brian Rosario, Oliver Beale, Amrish Selvam & Jay Chhablani

  3. School of Optometry and Vision Science, University of Waterloo, Waterloo, Canada

    Abdul Rasheed Mohammed

  4. Department of Retina and Vitreous, Narayana Nethralaya, Bengaluru, India

    Ramesh Venkatesh

  5. Department of Ophthalmology, Military Medical Academy, St. Petersburg, Russian Federation

    Dmitrii S. Maltsev

Authors
  1. Supriya Arora
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  2. Brian Rosario
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  3. Abdul Rasheed Mohammed
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  4. Oliver Beale
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  6. Ramesh Venkatesh
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  7. Dmitrii S. Maltsev
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Consortia

On behalf of Central Serous Chorioretinopathy Study Group

  • Supriya Arora
  • , Brian Rosario
  • , Abdul Rasheed Mohammed
  • , Oliver Beale
  • , Sumit Randhir Singh
  • , Amrish Selvam
  • , Gunjan Chhablani
  • , Ramesh Venkatesh
  • , Nikitha Reddy
  • , Alexei N. Kulikov
  • , Dmitrii S. Maltsev
  •  & Jay Chhablani

Corresponding author

Correspondence to Jay Chhablani.

Ethics declarations

Ethics approval

The study adhered to the tenets of the Declaration of Helsinki and ethical clearance was obtained by the institutional review board (University of Pittsburgh, Pittsburgh, USA; Independent Ethics Committee of Military Medical Academy, Russia; Narayana Nethralaya Eye Hospital, Bangalore, India, and Hyderabad Research Foundation, Hyderabad, India).

Consent to participate

Informed consent was obtained from all individual participants included in the study.

Consent for publication

Patients signed informed consent regarding publishing their data and photographs.

Conflict of interest

Dr Jay Chhablani is a consultant for Allergan, Salutaris MD, Novartis, and Biogen. The remaining authors have no proprietary or financial interest in any aspect of this report. No conflict of interest.

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Arora, S., Rosario, B., Mohammed, A.R. et al. Regression patterns of central serous chorioretinopathy using en face optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 260, 2475–2481 (2022). https://doi.org/10.1007/s00417-022-05636-3

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  • DOI: https://doi.org/10.1007/s00417-022-05636-3

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