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Screening of telangiectatic capillaries in chronic macular edema based on multimodal imaging: a study of 101 eyes. LyoMAC1 study

  • Retinal Disorders
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Abstract

Purpose

To estimate the prevalence of telangiectatic capillaries (TCs) in patients followed for chronic macular edema (CME) (diabetic ME [DME] and ME associated with retinal vein occlusion [RVO]).

Methods

Real-life, prospective, bi-centric cohort study including all consecutive patients followed for a clinically significant CME secondary to diabetic retinopathy or RVO. Inclusion criteria were patients treated with intravitreal injection for their ME for at least 12 months who had to undergo follow-up angiography. Multimodal imaging with color retinophotography, spectral-domain optical coherence tomography (SD-OCT), OCT angiography, and en face OCT was performed in all patients.

Results

A total of 101 eyes of 71 patients were included between November 2019 and June 2020. Of the 101 eyes analyzed, indocyanine green angiography found at least one TC in 67 eyes (66.3%). No significant differences were found between the groups with and without TC except for the distribution of DME and RVO (p < 0.008). In 83.6% of eyes with TCs, TCs contributed to the formation of the ME. SD-OCT sensitivity for TC detection was 94%.

Conclusion

In our study, the estimated prevalence of TCs in CME (DME and ME associated with RVO) was 66.3%, i.e., two-thirds of patients. SD-OCT was an excellent screening examination with a sensitivity of 94%.

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Acknowledgements

The authors thank the physicians who participated to the inclusion of the patients in center 1: Dr. H. Plas (Lyon), Dr. E. Rochet (Lyon), Dr. H. Bouvarel (Lyon), and Dr. N. Chirpaz, and in center 2: Dr. M. Guillaud (Lyon), Dr. A. Pauthenier (Lyon), Dr. M. Papegaey (Lyon), and Dr. M. Kern (Lyon).

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Authors and Affiliations

  1. Ophthalmology Department, Hôpital d’Instruction Des Armées Desgenettes, 108, Boulevard Pinel, 69003, Lyon, France

    Mayeul Chaperon, Emilie Agard, Jérémy Billant, Hussam El-Chehab & Corinne Dot

  2. Ophthalmology Department, Hôpital de La Croix Rousse, Hospices Civils de Lyon, Lyon, France

    Laurent Kodjikian & Thibaud Mathis

  3. Clinical Research Center, Hôpital de La Croix Rousse, Hospices Civils de Lyon, Lyon, France

    Pierre Pradat

  4. French Military Health Service Academy, Val de Grâce, Paris, France

    Hussam El-Chehab & Corinne Dot

Authors
  1. Mayeul Chaperon
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  2. Laurent Kodjikian
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  3. Emilie Agard
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  4. Thibaud Mathis
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  5. Jérémy Billant
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  6. Hussam El-Chehab
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  7. Pierre Pradat
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  8. Corinne Dot
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Contributions

MC, LK, and CD contributed to the conception and the study design. MC, EA, and HEC contributed to data acquisition and management. MC, TM, JB, and PP contributed to data analysis, result interpretation, and manuscript drafting. All authors contributed to manuscript drafting and its critical revision for final content.

Corresponding author

Correspondence to Corinne Dot.

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Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the French Society of Ophthalmology (IRB 00008855 Société Française d'Ophtalmologie IRB #1) and with the 1964 Helsinki Declaration and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare no competing interests.

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Chaperon, M., Kodjikian, L., Agard, E. et al. Screening of telangiectatic capillaries in chronic macular edema based on multimodal imaging: a study of 101 eyes. LyoMAC1 study. Graefes Arch Clin Exp Ophthalmol 260, 2501–2508 (2022). https://doi.org/10.1007/s00417-022-05592-y

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  • DOI: https://doi.org/10.1007/s00417-022-05592-y

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