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Quantitative analysis of choroidal blood flow parameters in optical coherence tomography and angiography in central serous chorioretinopathy

  • Retinal Disorders
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A Correction to this article was published on 21 March 2022

This article has been updated

Abstract

Purpose

To evaluate the choriocapillaris (CC) flow in central serous chorioretinopathy (CSC) and determine the relationship between CC flow void with the choroidal thickness (CT) and choroidal vascularity index (CVI).

Methods

Retrospective analysis of 20 patients with CSC (40 eyes, including unaffected fellow eyes) and 20 age- and sex-matched controls. After compensation with optical coherence tomography (OCT) en-face structural image, the CC flow void (%) was measured using the phansalkar threshold with a window radius of 3 and 15 pixels. The mean CC flow voids of acute CSC, recovered-acute CSC, unaffected fellow, and control eyes were compared by matched data analysis. A regression analysis was performed on the choroidal parameters (CT and CVI) and CC flow voids.

Results

The CC flow void had an increasing tendency in the following order: control, fellow, recovered-acute CSC, and acute CSC eyes. Acute/recovered comparison showed a significant P value (0.008) in the foveal lesion. Recovered/fellow and fellow/control presented significant P values regardless of location to fovea (all <0.05). There were significant positive correlations between CT and CC flow void (P < 0.05) in the acute CSC, recovered-acute CSC eyes.

Conclusion

The CC flow on OCT angiography decreased in acute CSC eyes, especially in the foveal lesion, with a published compensation method. The findings suggest that unmodulated choroidal blood flow contributed to partially reversible diminished CC flow.

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Funding

This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF-2020R1F1A1074898).

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, The Catholic University of Korea School of Medicine, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea

    Bo-Een Hwang, Jae-Hyuck Kwak, Joo-Young Kim, Rae-Young Kim, Mirinae Kim, Young-Geun Park & Young-Hoon Park

  2. Catholic Institute for Visual Science, The Catholic University of Korea School of Medicine, Seoul, Republic of Korea

    Bo-Een Hwang, Jae-Hyuck Kwak, Joo-Young Kim, Rae-Young Kim, Mirinae Kim, Young-Geun Park & Young-Hoon Park

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  1. Bo-Een Hwang
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Correspondence to Young-Hoon Park.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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Owing to the retrospective nature of image analysis and anonymized data of this study, written informed consent procedures were exempted.

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The original version of this article was revised. Table 3 is now corrected.

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Hwang, BE., Kwak, JH., Kim, JY. et al. Quantitative analysis of choroidal blood flow parameters in optical coherence tomography and angiography in central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 260, 2111–2120 (2022). https://doi.org/10.1007/s00417-022-05588-8

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