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Risk factors of persistent subretinal fluid after half-dose photodynamic therapy for treatment-naïve central serous chorioretinopathy

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the prognostic factors on spectral domain optical coherence tomography (SD-OCT) associated with incomplete subretinal fluid (SRF) absorption in treated-naïve eyes with central serous chorioretinopathy (CSC) after the half-dose verteporfin photodynamic therapy (vPDT).

Methods

Patients with CSC who underwent half-dose vPDT with a follow-up period of more than 3 months were included in this retrospective study. Logistic regression was performed to determine the risk factors associated with the SRF persistence at 3 months after the treatment.

Results

A total of 143 patients with 150 eyes were enrolled in this study (102 male and 41 female patients). The rate of complete SRF resolution was 82.7% at 3 months for all cases. The duration of symptoms > 6 months (odds ratio [OR] = 3.135, 95% confidence interval [95% CI] (1.147–8.573), p = 0.026), larger SRF area with base diameter > 3 mm (odds ratio (OR) = 4.051, 95% CI: 1.336–12.284, p = 0.013), and larger flat irregular pigment epithelium detachment (FI-PED) area with base diameter > 1 mm (OR = 3.311, 95% CI: 1.249–8.780, p = 0.016) on OCT B-scans were risk factors for incomplete SRF absorption after half-dose vPDT, while outer nuclear layer (ONL) thickness was not significantly associated with the anatomical outcome (OR = 1.015, 95% CI: 0.995–1.036, p = 0.145).

Conclusion

The duration of symptoms, baseline SRF, and FI-PED base diameter on SD-OCT were important predictors for the anatomical outcome at 3 months after half-dose vPDT. Further studies are needed to establish a better therapeutic strategy for patients with poor response to half-dose vPDT.

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Funding

The study was supported by the capital clinical diagnosis and treatment technology research and demonstration application project of China (Grant Z191100006619029). The funder had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Department of Ophthalmology, Peking University People’s Hospital, Eye Diseases and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, No. 11 S Ave of XiZhiMen, XiCheng District, Beijing, 100044, People’s Republic of China

    Mengyang Li, Jinfeng Qu, Zhiqiao Liang, Jiyang Tang, Jie Hu, Yuou Yao, Enzhong Jin, Xiaoxin Li & Mingwei Zhao

Authors
  1. Mengyang Li
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  2. Jinfeng Qu
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  3. Zhiqiao Liang
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  5. Jie Hu
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  7. Enzhong Jin
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  8. Xiaoxin Li
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  9. Mingwei Zhao
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Contributions

Conceptualization: Mengyang Li and Jinfeng Qu.

Methodology: Jinfeng Qu.

Formal analysis and investigation: Mengyang Li, Jinfeng Qu, and Zhiqiao Liang.

Writing—original draft preparation: Mengyang Li, Jie Hu, and Jiyang Tang.

Writing—review and editing: Enzhong Jin, Yuou Yao, and Mingwei Zhao.

Funding acquisition: Jinfeng Qu.

Resources: Xiaoxin Li and Mingwei Zhao.

Supervision: Xiaoxin Li and Mingwei Zhao.

All authors have read and approved the content and agree to submit for publication in the journal.

Corresponding author

Correspondence to Mingwei Zhao.

Ethics declarations

Ethics approval

This retrospective study was approved by the Peking University People’s Hospital Review Board and adhered to the tenets of the Declaration of Helsinki and Health Insurance Portability and Accountability Act.

Consent to participate

Written informed consent was obtained from all individual participants included in the study.

Competing interests

The authors declare no competing interests.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Mengyang Li and Jinfeng Qu contributed equally to the work presented here and should therefore be regarded as equivalent first authors.

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Li, M., Qu, J., Liang, Z. et al. Risk factors of persistent subretinal fluid after half-dose photodynamic therapy for treatment-naïve central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 260, 2175–2182 (2022). https://doi.org/10.1007/s00417-021-05531-3

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  • DOI: https://doi.org/10.1007/s00417-021-05531-3

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