To investigate hyperreflective choroidal foci (HCF) using en face swept-source optical coherence tomography (SS-OCT) and determine the factors that contribute to the distribution of HCF in normal eyes.
In this retrospective study, we included healthy eyes with a normal fundus. HCF were defined as hyperreflective spots on en face SS-OCT images. The number, mean area, total area, and circularity of the HCF were compared with various choroid measurements obtained using SS-OCT, SS-OCT angiography, and fundus photography.
We investigated 51 eyes from 51 patients. The mean patient age was 56.0 ± 14.7 years, and 32 (62.7%) were female. The number and total area of HCF did not differ between the female and male patients and the right and left eyes. The number of HCF was correlated with the stromal area of the choroid (r = 0.291, P = 0.040) and subfoveal choroidal vascularity index (r = − 0.364, P = 0.009). The total area of HCF was correlated with the stromal area of the choroid (r = 0.283, P = 0.045). However, the number and total area of HCF were not correlated with age, degree of macular tessellation, subfoveal choroidal thickness, and choriocapillaris vascular density and flow void area.
HCF were observed in normal eyes, and their distribution was associated with the underlying stromal component of the choroid. The results of this study can be used as a reference for determining abnormal hyperreflective foci in the choroid of the eyes with various diseases.
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We had full access to all the data in the study and take responsibility for the integrity of the data, the accuracy of the data analysis, and decision to submit for publication. The datasets generated and/or analysed during the current study are available from the corresponding author upon reasonable request.
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This work was supported by the Korea Medical Device Development Fund grant funded by the Korean government (Ministry of Science and ICT, Ministry of Trade, Industry and Energy, Ministry of Health & Welfare, Ministry of Food and Drug Safety) (Project Number: 1711137942, KMDF_PR_20200901_0026).
This study was performed in accordance with the principles of the Declaration of Helsinki and approved by the Institutional Review Board of Korea University Anam Hospital, Seoul, Korea (IRB number: 2020AN0445).
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This retrospective study involved no more than minimal risk to subjects, and the IRB of Korea University Anam Hospital approved our request to waive off the requirement of informed consent.
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Kim, Y.H., Oh, J. Hyperreflective foci in the choroid of normal eyes. Graefes Arch Clin Exp Ophthalmol (2021). https://doi.org/10.1007/s00417-021-05469-6
- Choroidal vascularity
- Fundus tessellation
- Hyperreflective foci
- Swept-source optical coherence tomography