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Morphological differences of choroid in central serous chorioretinopathy determined by ultra-widefield optical coherence tomography

  • Medical Ophthalmology
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Abstract

Purpose

The purpose of this study was to compare the morphology of the central and peripheral choroid of eyes with central serous chorioretinopathy (CSC) to that of normal eyes using ultra-widefield optical coherence tomography (UWF-OCT).

Methods

We reviewed the medical records of 29 eyes of 25 patients (23 men, 2 women; average age 44.4 years) with CSC and 34 eyes of 22 healthy subjects (19 men, 3 women; average age, 49.5 years) with normal eyes. The images obtained by a prototype swept source UWF-OCT (Topcon, Tokyo, Japan) of about 31.5-mm wide and a depth of 10.9 mm were analyzed. The choroidal thickness was measured for each sector of the eye using the conventional automated layer analysis method. The local morphological differences were quantified by the maximum steepness (µm/deg) which was obtained by differentiating the changes in the choroidal thickness from the periphery to the fovea. Only the vertical scans were evaluated to avoid the influence of the optic disc.

Results

The choroid was thicker in the macular area than the peripheral area in both normal and CSC eyes. The choroid at the subfovea was significantly thicker in the CSC eyes than that of the normal eyes (P < 0.0001); however, the difference at the periphery was not significant. The mean of the maximum steepness of the choroidal thickness was 20.8 ± 3.8 µm/deg in the CSC eyes which was significantly steeper than the 16.0 ± 4.6 µm/deg in healthy eyes (P < 0.0001).

Conclusion

The choroid in CSC eyes has a steeper slope around the posterior pole. UWF-OCT can be used to evaluate the abnormalities of the choroidal structures from the posterior pole to the periphery in eyes with CSC.

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Acknowledgements

The authors thank Professor Emeritus Duco Hamasaki of the Bascom Palmer Eye Institute, University of Miami, for his critical discussion and editing of the revised manuscript.

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Authors and Affiliations

  1. Department of Ophthalmology, Tokyo Women’s Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Takahiko Izumi, Ichiro Maruko, Taizo Kawano & Tomohiro Iida

  2. Topcon Corporation, 75-1, Hasunumacho, Itabashi-ku, Tokyo, 174-8580, Japan

    Manabu Sakaihara

Authors
  1. Takahiko Izumi
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  2. Ichiro Maruko
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  3. Taizo Kawano
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  4. Manabu Sakaihara
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  5. Tomohiro Iida
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Corresponding author

Correspondence to Ichiro Maruko.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Board of the Tokyo Women’s Medical University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Conflict of interest

Izumi: Personal fees from Novartis (Japan), Senju (Japan), outside the submitted work.

Maruko: Grants from JSPS KAKENHI (Grant Number JP 20K09781), grants and personal fees from Alcon Pharma (Japan), personal fees from Bayer Yakuhin, Ltd. (Japan), personal fees from Santen Pharmaceutical Inc. (Japan), personal fees from Alcon Japan, Ltd., personal fees from Topcon Co., Ltd. (Japan), personal fees from Senju Pharmaceutical Co. (Japan), Ltd., personal fees from NIDEK Co., Ltd. (Japan), outside the submitted work. Maruko has a patent Peripheral retinal imaging system pending.

Kawano: Personal fees from Senju (Japan), outside the submitted work.

Sakaihara: Employee by Topcon Corp.

Iida.: Consultant- Bayer (Japan), Chugai (Japan); Research support from Topcon (Japan); Personal fees from Bayer (Japan), Novartis (Japan), Nidek (Japan), Kowa (Japan), Canon (Japan), Topcon (Japan), Santen (Japan), Senju (Japan), Alcon (Japan), HOYA (Japan), AMO (Japan), Pfizer (Japan), Otsuka (Japan), JFC (Japan), Nikon (Japan), outside the submitted work. Iida has a patent Peripheral retinal imaging system pending.

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Cite this article

Izumi, T., Maruko, I., Kawano, T. et al. Morphological differences of choroid in central serous chorioretinopathy determined by ultra-widefield optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 260, 295–301 (2022). https://doi.org/10.1007/s00417-021-05380-0

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  • DOI: https://doi.org/10.1007/s00417-021-05380-0

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