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Novel area-based optic nerve head parameter to distinguish glaucoma from non-glaucomatous retinal nerve fiber layer defect in branch retinal vein occlusion

  • Glaucoma
  • Published:
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Abstract

Purpose

The purpose of this study was to assess the diagnostic ability of the new area-based parameter retinal nerve fiber layer to disc ratio (RDR) for discriminating between glaucoma and non-glaucomatous retinal nerve fiber layer defects (RNFLDs).

Methods

This retrospective cross-sectional study included 42 branch retinal vein occlusion (BRVO) eyes with RNFLD, 42 open-angle glaucoma (OAG) eyes, and 42 healthy control eyes that were matched with optic disc size. The RDR, peripapillary retinal nerve fiber layer thickness (pRNFLT), Bruch’s membrane opening-minimum rim width (BMO-MRW), and Bruch’s membrane opening-minimum rim area (BMO-MRA) were analyzed. The areas under the receiver operating characteristic curves (AUCs) were calculated for each parameter.

Results

The OAG and BRVO groups had similar global pRNFLT (87.57 ± 7.07 µm and 89.71 ± 12.21 µm, respectively), but these were thinner than those of the healthy group (102.71 ± 8.95 µm, p < 0.001 and p < 0.001, respectively). RDR was lowest in the BRVO group (0.755 ± 0.121, p < 0.001) and highest in the OAG group (1.111 ± 0.145, p < 0.001). Global BMO-MRW was significantly lower in the OAG group (194.36 ± 23.09 µm) than in the BRVO (269.69 ± 42.77 µm, p < 0.001) and healthy (273.48 ± 30.92 µm, p < 0.001) groups. Total BMO-MRA of the OAG group (0.88 ± 0.12 mm2) was significantly lower than that of the BRVO (1.32 ± 0.19 mm2, p < 0.001) and healthy (1.30 ± 0.21 mm2, p < 0.001) groups. AUC for discriminating between the OAG and BRVO was 0.986 for total BMO-MRA and 0.970 for RDR (p = 0.192).

Conclusion

In clinical practice, RDR may perform well as a parameter to distinguish between glaucoma and non-glaucomatous RNFLD.

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Data availability

All research data is available and complies with standards.

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Authors and Affiliations

  1. Department of Ophthalmology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 150, Seongan-ro, Gangdong-gu, Seoul, 05355, South Korea

    Yerim An, Sung Pyo Park & Kyeong Ik Na

Authors
  1. Yerim An
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  2. Sung Pyo Park
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Contributions

Study design: K.I.N., P.S.P.

Collection, management, analysis, and interpretation of the data: Y.A., K.I.N.

Preparation of manuscript: Y.A., K.I.N.

Review and approval of manuscript: all.

Corresponding authors

Correspondence to Sung Pyo Park or Kyeong Ik Na.

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This article does not contain any studies with human participants or animals performed by any of the authors.

Conflict of interest

Author P.S.P. was supported by the Korean Association of Retinal Degeneration.

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Sung Pyo Park and Kyeong Ik Na contributed equally as corresponding authors

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An, Y., Park, S.P. & Na, K.I. Novel area-based optic nerve head parameter to distinguish glaucoma from non-glaucomatous retinal nerve fiber layer defect in branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 260, 235–246 (2022). https://doi.org/10.1007/s00417-021-05341-7

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  • DOI: https://doi.org/10.1007/s00417-021-05341-7

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