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Relationship between the vessel density around the optic nerve head and visual field deterioration in eyes with retinitis pigmentosa

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To analyze the vessel density around the optic nerve head (ONH) by optical coherence tomography angiography (OCTA) in patients with retinitis pigmentosa (RP), and to evaluate its correlation with visual functions.

Methods

Thirty-eight eyes with RP with visual field constriction within the central 10° were enrolled. The mean (± SD) age of the patients was 43.7 ± 15.1 years. In addition to visual acuity (VA) measurements and visual field tests (Humphrey Field Analyzer 10–2 test), we also measured the vessel density at the macula by OCTA (superficial and deep vessel density: sVD(m) and dVD(m)) and in multiple layers around the ONH (vessel density in the radial peripapillary capillary [RPC] layer and in the nerve head [NH] layer: VDrpc and VDnh). The vessel density was calculated by binarizing the OCTA images. The associations between the logMAR VA and mean deviation (MD) values and the variables of central retinal thickness (CRT), sVD(m), dVD(m), VDrpc, VDnh, and also the size of the foveal avascular zone were investigated.

Results

The mean logMAR VA was 0.16 ± 0.34 and the MD value was − 17.2 ± 10.3 dB; the MD value was significantly related to the logMAR VA (p = 0.0028). Multivariate analysis with AICc model selection suggested only dVD(m) was associated with logMAR VA. On the other hand, the optimal model for the MD value included the CRT, dVD(m), and VDnh.

Conclusion

The vessel density in the deep layer around the ONH was significantly associated with the visual field deterioration in patients with RP.

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Authors and Affiliations

  1. Department of Ophthalmology, The University of Tokyo, Tokyo, Japan

    Kosuke Nakajima, Tatsuya Inoue, Asako Ogawa, Yohei Hashimoto, Keiko Azuma, Ryo Terao, Ryo Asaoka & Ryo Obata

  2. Department of Ophthalmology and Micro-Technology, Yokohama City University School of Medicine, 4-57 Urafune, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan

    Tatsuya Inoue, Maiko Maruyama-Inoue, Yasuo Yanagi & Kazuaki Kadonosono

  3. Department of Ophthalmology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan

    Ryo Asaoka

  4. Seirei Christopher University, Hamamatsu, Shizuoka, Japan

    Ryo Asaoka

Authors
  1. Kosuke Nakajima
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  2. Tatsuya Inoue
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  3. Maiko Maruyama-Inoue
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  4. Yasuo Yanagi
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  5. Kazuaki Kadonosono
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  6. Asako Ogawa
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  7. Yohei Hashimoto
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  8. Keiko Azuma
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  9. Ryo Terao
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  10. Ryo Asaoka
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  11. Ryo Obata
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Corresponding author

Correspondence to Tatsuya Inoue.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Research Ethics Committee of the Graduate School of Medicine and Faculty of Medicine at The University of Tokyo and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Nakajima, K., Inoue, T., Maruyama-Inoue, M. et al. Relationship between the vessel density around the optic nerve head and visual field deterioration in eyes with retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol 260, 1097–1103 (2022). https://doi.org/10.1007/s00417-021-05288-9

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  • DOI: https://doi.org/10.1007/s00417-021-05288-9

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