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Intralesional diode laser pretreatment facilitates surgery for orbital venous malformations: initial experience with 23 consecutive patients

  • Medical Ophthalmology
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

This study aims to evaluate the efficacy and safety of intralesional diode laser pretreatment for facilitating surgery for orbital venous malformations (OVMs).

Methods

This is a retrospective, non-comparative, interventional cohort involving 23 consecutive OVM patients undergoing intralesional laser pretreatment followed by surgical excision. The main outcome measures included volumetric changes, exophthalmometry, cosmesis, and symptom scores as well as treatment-related adverse events.

Results

Following intralesional diode laser, the mean volume dropped significantly from 2366 ± 1887 to 129 ± 119 mm3 (t = 5.716; p < 0.001). After a single treatment session, a mean 90 ± 13% volume shrinkage was achieved in all 23 OVM. The mean Hertel exophthalmometry decreased significantly from 14 ± 3 to 13 ± 1 mm (t = 2.515; P < 0.02). The resolution of periocular dyschromasia and swelling were evident in 20 patients (87%). Symptom scores improved significantly from 6.5 ± 1.4 (very intense discomfort or effect on daily living) to 1.2 ± 1.0 (very mild discomfort or effect on daily living; p < 0.001). Short-term bruises and swelling were reported in 20 patients (87%).

Conclusion

Intralesional laser pretreatment is effective to facilitate surgery especially for the deep involving orbital venous malformations.

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Abbreviations

BCVA:

Best-corrected visual acuity

CT:

Computed tomography

MRI:

Magnetic resonance imaging

OVM:

Orbital venous malformation

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Acknowledgements

We would like to include the surgery team of the ophthalmology department for their exquisite surgery and good care of the patients. We were grateful of the pathology department and the radiology department for offering fine reports. Medical editor Katharine O’Moore-Klopf, ELS (East Setauket, NY, USA), provided professional English language editing of the manuscript.

Funding

The present study was supported by the National Natural Science Foundation of China (grant number 81570884, 81872339, 81802702), Shanghai Sailing Program (grant number 17YF1410700), and Interdisciplinary Program of Shanghai Jiao Tong University (YG2016MS02), hospital-level nursing research projects funded by Shanghai 9th People’s Hospital (JYHL20161914), the “top priority” in nursing research projects funded by Shanghai Jiaotong University, School of Medicine (JYHZ1814).

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Author notes

  1. Minyue Xie, Tianyuan Li contributed equally to this work.

Authors and Affiliations

  1. Department of Ophthalmology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

    Minyue Xie, Tianyuan Li, Yingxiu Luo, Yinwei Li, Yefei Wang, Xianqun Fan & Renbing Jia

  2. Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

    Ludwig M. Heindl

  3. Center for Integrated Oncology (CIO) Aachen-Bonn-Cologne-Dusseldorf, Cologne, Germany

    Ludwig M. Heindl

  4. Department of Ophthalmology, Ninth People’s Hospital, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, 200025, China

    Renbing Jia

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  1. Minyue Xie
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Contributions

Renbing Jia and Ludwig M. Heindl designed the study and made detailed plan. Yinwei Li, Yefei Wang, and Xianqun Fan checked and operated on the patients. Yingxiu Luo collected the patients’ information. Minyue Xie and Tianyuan Li reviewed all data and wrote the manuscript.

Corresponding authors

Correspondence to Ludwig M. Heindl or Renbing Jia.

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Ethics approval and consent to participate

All procedures performed in studies involving human participants were in accordance with the ethical standards of the ethics committee of the institutional ethical review board of Shanghai Ninth People’s Hospital.

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The authors declare no competing interests.

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Xie, M., Li, T., Luo, Y. et al. Intralesional diode laser pretreatment facilitates surgery for orbital venous malformations: initial experience with 23 consecutive patients. Graefes Arch Clin Exp Ophthalmol 260, 303–309 (2022). https://doi.org/10.1007/s00417-021-05272-3

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  • DOI: https://doi.org/10.1007/s00417-021-05272-3

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