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May ganglion cell complex analysis be a marker for glaucoma susceptibility in unilateral Fuchs’ uveitis syndrome?

  • Inflammatory Disorders
  • Published:
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Abstract

Purpose

To compare retinal nerve fiber layer (RNFL) thickness and ganglion cell-inner plexiform layer thickness (GCIPLT) in the affected eyes to fellow unaffected eyes of patients with unilateral Fuchs’ uveitis syndrome (FUS) and analyze their change over time.

Methods

Twenty seven unilateral FUS patients who did not have concomitant systemic or ocular disease were retrospectively enrolled. Central macular thickness (CMT), RNFL thickness, and GCIPLT measurements were evaluated. Data was analyzed using the non-parametric Brunner-Langer model (LD-F2 design) and Wilcoxon signed-rank test.

Results

The mean age of the patients was 40.2 ± 10.2 years. The median disease duration was 11 (2–62) months. The median best-corrected visual acuity (BCVA) of the affected eyes and the fellow eyes was 0.22 (0.00–2.50) vs. 0.00 (0.0–0.10) logMAR at the initial visit and 0.05 (0.00–2.50) vs. 0.00 (0.0–0.30) logMAR at the final visit. The change in BCVA was found significant in the affected eyes, but not in the fellow eyes (p < 0.001 and p = 0.287, respectively). The median CMT in the affected eyes at the final visit was not statistically different from the value at the initial visit (255 (157–306) vs. 245 (140–310) µm, p = 0.256). The change in RNFL thickness over time in the affected eyes was similar to the fellow unaffected eyes of the patients with unilateral FUS at all quadrants, with non-significant time and group effects (p > 0.05). However, median GCIPLT in all quadrants (except superonasal) in the affected eyes was statistically lower than the fellow eyes at the initial and final visits (p < 0.05). The most affected quadrant of the ganglion cell complex was inferonasal in the involved eyes (79 (42–97) vs. 75 (43–87) µm) at initial and final visits (p = 0.033 for time effect and p < 0.001 for group effect, respectively).

Conclusion

Median CMT and RNFL thickness did not change during follow-up in the affected eyes of patients with unilateral FUS. Median GCIPLT in the affected eyes declined over time in all quadrants. Ganglion cell loss was also most prominent in the inferonasal quadrant in the affected eyes. FUS patients should be followed up long-term in terms of ganglion cell loss, especially in the inferonasal quadrant.

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Data availability

All of the authors in this manuscript have full control of all primary data and agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review their data if requested.

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Authors and Affiliations

  1. Ophthalmology, Ataturk Training and Research Hospital, Izmir Katip Celebi University, Basın Sitesi Mah, Hasan Tahsin Cad No: 143, 35150, Karabaglar, Izmir, Turkey

    Melike Balikoglu Yilmaz, Seher Saritepe Imre & Erdinc Aydin

  2. Ophthalmology, Manisa State Hospital, Manisa, Turkey

    Nur Doganay Kumcu

  3. Ophthalmology, Training and Research Hospital, Usak University, Usak, Turkey

    Hatice Daldal

  4. Department of Biostatistics and Medical Informatics, Ege University, Izmir, Turkey

    Semiha Ozgul & Timur Kose

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  1. Melike Balikoglu Yilmaz
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This paper was presented as an oral presentation at the International Council of Ophthalmology World Ophthalmology Congress on 26–29 June 2020.

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Balikoglu Yilmaz, M., Doganay Kumcu, N., Daldal, H. et al. May ganglion cell complex analysis be a marker for glaucoma susceptibility in unilateral Fuchs’ uveitis syndrome?. Graefes Arch Clin Exp Ophthalmol 259, 1975–1983 (2021). https://doi.org/10.1007/s00417-021-05182-4

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  • DOI: https://doi.org/10.1007/s00417-021-05182-4

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