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Monocular and binocular visual parameters associated to vision-related quality of life in patients with epiretinal membrane: a prospective cohort

Graefe's Archive for Clinical and Experimental Ophthalmology volume 259, pages 1723–1730 (2021)Cite this article

Abstract

Purpose

Binocular visual impairment related to unilateral idiopathic epiretinal membranes (uiERM) and its association with vision-related quality of life (VR-QoL) has not yet been investigated. This study aimed to explore binocular visual parameters (distance binocular best-corrected visual acuity (BCVA), aniseikonia, stereopsis) and VR-QoL in patients with uiERM.

Methods

We carried out a prospective single-centre cohort study. The following data were collected: VR-QoL (NEI VFQ-25), distance monocular and binocular BCVA, horizontal and vertical metamorphopsia (M-charts test), horizontal and vertical aniseikonia (NAT TEST) and stereoacuity (TNO test). Multiple linear regression analyses were performed to evaluate factors influencing VR-QoL.

Results

Forty-six patients with uiERM and visual complaints were included. Aniseikonia was found in 40 (80%) participants. Stereoacuity was poor (above 120 s of arc) in 46 (100%) participants. Distance monocular BCVA, horizontal metamorphopsia and horizontal aniseikonia were the factors associated with VR-QoL in patients with uiERM.

Conclusions

In subjects presenting uiERM, aniseikonia is frequently found and stereopsis is constantly impaired. We advocate quantitative testing of metamorphopsia and aniseikonia in addition to BCVA for the assessment of global visual function. Further investigations are needed to evaluate the effect of vitrectomy on these parameters and VR-QoL.

Trial registration

EudraCT Number/ID RCB: 2016-A00252-49

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Affiliations

  1. Department of Ophthalmology, Bretonneau University Hospital, 2 boulevard Tonnellé, 37044, Tours, France

    Raoul Kanav Khanna, Tiphanie Pichard, Marta Dorvault, Ann-Rose Cook, Pierre-Jean Pisella & Sophie Arsene

  2. Neurogénétique et Physiopathologie neuronale, iBrain, INSERM, U1253, University of Tours, Tours, France

    Raoul Kanav Khanna

  3. Clinical Data Center, SIMEES, Centre Hospitalier Régional Universitaire, Bretonneau University Hospital, Tours, France

    Jeremy Pasco

Authors
  1. Raoul Kanav Khanna
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  2. Tiphanie Pichard
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Correspondence to Raoul Kanav Khanna.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of the University Hospital of Tours, France and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Khanna, R.K., Pichard, T., Pasco, J. et al. Monocular and binocular visual parameters associated to vision-related quality of life in patients with epiretinal membrane: a prospective cohort. Graefes Arch Clin Exp Ophthalmol 259, 1723–1730 (2021). https://doi.org/10.1007/s00417-020-05064-1

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  • DOI: https://doi.org/10.1007/s00417-020-05064-1

Keywords

  • Epiretinal membrane
  • Quality of life
  • Stereopsis
  • Aniseikonia
  • Binocularity