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Choroidal thickening in retinal vein occlusion patients with serous retinal detachment

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate choroid thickness and macular retinal metrics in treatment naïve retinal vein occlusion (RVO) patients with serous retinal detachment (SRD) before and after intravitreal anti-vascular endothelial cell growth factor (VEGF) injection and to elucidate the possible role of choroid in the development of SRD and the potential role of SRD as a prognostic parameter.

Methods

This is a retrospective study involving 85 RVO patients, 41 central retinal vein occlusion (CRVO), and 44 branch retinal vein occlusion (BRVO), with macular edema: 21 central retinal vein occlusion and 22 branch retinal vein occlusion with SRD and the rest without SRD. Patients were evaluated with ophthalmic examinations and swept-source optical coherence tomography (SS-OCT) both before and 4–6 weeks after intravitreal anti-VEGF treatment. Choroid thickness and retinal metrics were measured and compared between SRD and non-SRD groups within each RVO subtype.

Results

In both CRVO and BRVO patients, the mean central subfield foveal thickness (CSFT) and central subfoveal choroid thickness (CSCT) of the SRD groups were thicker than those in the non-SRD groups (p < 0.05) at onset. After one anti-VEGF injection, CSFT and FNRT decreased in all groups (p < 0.05). The CSCTs were thicker in the SRD groups compared with the non-SRD groups (p < 0.05). The mean changes of CSFT were more remarkable in the SRD groups (p < 0.05).

Conclusion

Thicker choroid was a feature of naïve RVO patients with SRD and SRD may be an indicator of better anatomical recovery of retina in RVO patients after a single dose of anti-VEGF treatment.

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Data availability

The datasets presented in this study are available from the corresponding author upon request.

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Funding

This work is supported by the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2018PT32029).

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China

    Lulu Chen, Mingzhen Yuan, Lu Sun & Youxin Chen

  2. Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China

    Lulu Chen, Mingzhen Yuan, Lu Sun & Youxin Chen

Authors
  1. Lulu Chen
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  2. Mingzhen Yuan
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  3. Lu Sun
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  4. Youxin Chen
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Contributions

LLC interpreted the data, drafted this manuscript, and reviewed the literature. MZY helped design the work. MZY and LS collected the data. LLC and SL analyzed the data. MZY revised the manuscript. YXC had the final approval. All authors have read and approved the final manuscript.

Corresponding author

Correspondence to Youxin Chen.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study adhered to the tenets of the Declaration of Helsinki and was approved by PUMCH. Informed consent was obtained from all subjects. The research was approved by the institutional review board of PUMCH (approval number: S-K631).

Consent to participate

Written informed consents were obtained from all participants for participating in this study.

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Written informed consents were obtained from all participants for the publication of clinical information and images.

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Chen, L., Yuan, M., Sun, L. et al. Choroidal thickening in retinal vein occlusion patients with serous retinal detachment. Graefes Arch Clin Exp Ophthalmol 259, 883–889 (2021). https://doi.org/10.1007/s00417-020-04983-3

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  • DOI: https://doi.org/10.1007/s00417-020-04983-3

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