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Multicolor imaging in macular telangiectasia—a comparison with fundus autofluorescence

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To describe various clinical features of idiopathic juxtafoveal retinal telangiectasis group 2A or idiopathic macular telangiectasia type 2 (MacTel) on multicolor imaging (MCI) and compare imaging findings of MacTel on MCI with fundus autofluorescence (FAF).

Methods

Patients with a clinical diagnosis of MacTel based on Gass and Blodi’s classification were included. FAF and MCI images were graded qualitatively for stage of disease, margins of involvement, hyperautofluorescence on FAF (corresponding retinal atrophy on MCI), and detection of crystals. FAF and MCI were graded quantitatively for the area and number of quadrants involved, hypoautofluorescene on FAF (corresponding intraretinal pigment hyperplasia or retinal pigment epithelium [RPE] atrophy on MCI), and foci of right-angled venules.

Results

Seventy-eight eyes of forty five patients were included with both imaging modalities showing no difference with respect to staging of non-proliferative MacTel. Retinal crystals were recognized on MCI but not on FAF. Neurosensory retinal atrophy and  subretinal neovascular membranes were detected using MCI with 92.3 and 83.3% sensitivity, respectively. Intraretinal pigmented hyperplasia was more accurately detected (70.1 vs 58.4%) compared with RPE atrophy on MCI. MCI showed larger area of involvement, higher number of quadrants involved (p < 0.001), and better delineation of margins (p = 0.002) compared with FAF. A higher mean number of vessel dipping foci was noted on MCI in comparison with FAF (3.34 vs 3.1).

Conclusion

Various parameters were more easily defined using MCI compared with FAF which qualifies MCI as an enface depth-resolved imaging adjunct to conventional multimodal imaging in MacTel. The ability to detect enface as well as cross-sectional imaging features makes MCI a valuable tool in MacTel.

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Authors and Affiliations

  1. Department of Retina, Pushpagiri Vitreo-Retina Institute, Hyderabad, India

    Vishal Govindahari

  2. Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, NSW, Australia

    Samantha Fraser-Bell

  3. Department of Vitreoretina, M. M. Joshi Eye Institute, Hubballi, Karnataka, India

    Apoorva G. Ayachit

  4. Eye Clinic - Department of Biomedical and Clinical Science “L. Sacco”, Luigi Sacco Hospital, University of Milan, Milan, Italy

    Alessandro Invernizzi & Mariano Cozzi

  5. Department of Retina, Chaithanya Eye Hospital and Research Institute, Trivandrum, Kerala, India

    Unnikrishnan Nair & Dhanya V. Nair

  6. Department of Ophthalmology, University of Perugia, Perugia, Italy

    Marco Lupidi

  7. Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, Institute, Hyderabad, India

    Sumit Randhir Singh

  8. Aravind Eye Care System, Chennai, India

    Anand Rajendran

  9. Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Dinah Zur

  10. Unit of Macula, Oftalvist Clinic, Valencia, Spain

    Roberto Gallego-Pinazo & Rosa Dolz Marco

  11. Department of Biomedical and Surgical Sciences, Section of Ophtalmology, S. Maria della Misericordia Hospital, University of Perugia, Perugia, Italy

    Carlo Cagini

  12. UPMC eye center, University of Pittsburg, 203 Lothrop Street, Pittsburgh, PA, 15213, USA

    Jay Chhablani

Authors
  1. Vishal Govindahari
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  2. Samantha Fraser-Bell
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  3. Apoorva G. Ayachit
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  4. Alessandro Invernizzi
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  7. Marco Lupidi
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  8. Sumit Randhir Singh
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  9. Anand Rajendran
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  10. Dinah Zur
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  11. Roberto Gallego-Pinazo
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  12. Rosa Dolz Marco
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  13. Carlo Cagini
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  14. Mariano Cozzi
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  15. Jay Chhablani
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Contributions

Guidelines for authorship adhered to as prescribed.

Corresponding author

Correspondence to Jay Chhablani.

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The authors declare that they have no conflict of interest.

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None.

Ethics approval

This research study was conducted retrospectively from data obtained for clinical purposes. We consulted extensively with the IRB of Pushpagiri Vitreo Retina Institute, India, who determined that our study did not need ethical approval. An IRB official waiver of ethical approval was granted from the IRB of Pushpagiri Vitreo Retina Institute, India.

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Govindahari, V., Fraser-Bell, S., Ayachit, A.G. et al. Multicolor imaging in macular telangiectasia—a comparison with fundus autofluorescence. Graefes Arch Clin Exp Ophthalmol 258, 2379–2387 (2020). https://doi.org/10.1007/s00417-020-04878-3

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  • DOI: https://doi.org/10.1007/s00417-020-04878-3

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