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Association of lateral rectus muscle volume and ocular motility with the abducens nerve in Duane’s retraction syndrome

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Abstract

Purpose

To investigate the relationship between ocular motility and lateral rectus (LR) muscle volume according to the presence or absence of the abducens nerve in patients with Duane’s retraction syndrome (DRS) using high-resolution magnetic resonance imaging (MRI).

Methods

A total of 54 unilateral DRS patients were divided into two groups according to high-resolution MRI findings: DRS without an abducens nerve on the affected side (absent CN6 group, n = 45) and DRS with symmetric abducens nerves on both sides (present CN6 group, n = 9). Ocular motility was measured by image analysis based on nine gaze photographs. LR volume was measured on T2-weighted coronal MRI of the orbit, and the ratio of paretic/normal side (P/N) LR volume was investigated. Association of the abducens nerve with various parameters including ocular motility, LR volume, and ratios of P/N LR volume were determined.

Results

LR volume was smaller in the affected eye than the non-affected eye in both groups. In the present CN6 group, abducens nerve diameter and the ratio of P/N LR volume showed a positive correlation. A smaller LR volume and more limitation of abduction in the affected eye were predictive of an absent abducens nerve in DRS.

Conclusions

LR muscle hypoplasia was apparent in the affected eye of DRS patients. Abducens nerve diameter positively correlated with the ratio of P/N LR volume in the present CN6 group.

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Funding

This work was supported by Seoul National University Bundang Hospital Research Fund (No. 02-2016-051), Seongnam, Korea.

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Authors and Affiliations

  1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea

    Hee Kyung Yang, Jounghan Kim, Dae-seung Lee & Jeong-Min Hwang

  2. Department of Ophthalmology, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam, Gyeonggi-do, 13620, Republic of Korea

    Hee Kyung Yang, Jounghan Kim, Dae-seung Lee & Jeong-Min Hwang

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  1. Hee Kyung Yang
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Correspondence to Jeong-Min Hwang.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of Seoul National University Bundang Hospital and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Hee Kyung Yang and Jounghan Kim are equivalent first authors.

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Yang, H.K., Kim, J., Lee, Ds. et al. Association of lateral rectus muscle volume and ocular motility with the abducens nerve in Duane’s retraction syndrome. Graefes Arch Clin Exp Ophthalmol 259, 205–211 (2021). https://doi.org/10.1007/s00417-020-04845-y

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  • DOI: https://doi.org/10.1007/s00417-020-04845-y

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