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Clinical features of simple hemorrhage and myopic choroidal neovascularization associated with lacquer cracks in pathologic myopia

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Abstract

Purpose

To investigate the clinical features of simple hemorrhage (SH) and myopic choroidal neovascularization (mCNV) lesions in pathologic myopia (PM) accompanied with lacquer cracks (LCs).

Methods

Altogether 105 PM subjects were recruited with fifty-eight eyes categorized as group LC + SH and sixty eyes as group LC + mCNV. LCs were categorized into stellate and linear subtypes. Eye fundus photography, optical coherence tomography, fluorescein angiography, and indocyanine green angiography were performed. Clinical demographic data, PM maculopathy, peripapillary atrophy, and macular choroidal thickness (mCT) were documented.

Results

Significant differences in age, gender, BCVA, and PM atrophies were observed between LC + SH and LC + mCNV groups. The stellate LC was more common in elder subjects with more severe chorioretinal atrophy and thinner mCT compared with linear LCs (P < 0.05). The mCT in group LC + SH was significantly larger than group LC + CNV (P < 0.001), especially in temporal, inferior, and superior locations of macula. The mCT showed correlation with age (P < 0.001)with a decreasing rate of 0.696 μm/year.

Conclusions

SH tended to initially occur in younger subjects with linear LCs. mCNV was more common in elder subjects with severe chorioretinal atrophy. Stellate LCs were associated with the worse PM lesions.

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Funding

This study was funded by the National Science Foundation of China (81670842) and Science and the Technology Project of Zhejiang Province (2019C03046).

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Author notes

  1. Peifang Ren and Li Lu contributed equally to this work and should be regarded as co-first authors.

Authors and Affiliations

  1. Department of Ophthalmology, the First Affiliated Hospital, School of Medicine,|, Zhejiang University, 79 Qingchun Road, Zhejiang, 310003, Hangzhou, China

    Peifang Ren, Li Lu, Xuyuan Tang, Hong Lu, Yuan Zhao, Dinghua Lou & Wei Han

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  1. Peifang Ren
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  2. Li Lu
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  3. Xuyuan Tang
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  4. Hong Lu
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  6. Dinghua Lou
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  7. Wei Han
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Correspondence to Dinghua Lou or Wei Han.

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Ethical approval

The study was approved by the Ethics Committee of the First-Affiliated Hospital, College of Medicine, Zhejiang University(Reference NO. 2019-1561)and performed in accordance with the tenets of the Declaration of Helsinki. This type of study does not require informed consent.

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Ren, P., Lu, L., Tang, X. et al. Clinical features of simple hemorrhage and myopic choroidal neovascularization associated with lacquer cracks in pathologic myopia. Graefes Arch Clin Exp Ophthalmol 258, 2661–2669 (2020). https://doi.org/10.1007/s00417-020-04778-6

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  • DOI: https://doi.org/10.1007/s00417-020-04778-6

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