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Evaluation of choroidal thickness and choroidal vascular blood flow in patients with thyroid-associated orbitopathy (TAO) using SD-OCT and Angio-OCT

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The aim of this study was to evaluate changes in choroidal thickness and in choroidal vascular blood flow in patients with thyroid-associated orbitopathy (TAO) and their relationship with clinical features and disease activity using spectral domain optical coherence tomography (SD-OCT) and Angio-OCT technology.


Eighteen patients and control subjects underwent a complete eye examination, OCT, and Angio-OCT. We also obtained angiographic scans at 3 different consecutive levels (L1, L2, and L3) below the choriocapillary.


The subfoveal choroid was significantly thicker in TAO patients than the control eyes (285.6275 ± 32.5 μm compared with 135.89 ± 19.8 μm, respectively, p = 0.0089). The correlation analysis in the TAO group showed a significant correlation between the choroidal thickness and EUGOGO clinical score (r = 0.84, p = 8.44032E-07). Vascular flow of choriocapillary was markedly reduced in subjects with TAO compared with healthy subjects (49.78 ± 4.5 vs. 53.36 ± 1.07; p = 2.5105E-07) and vascular flow of the deeper layer L3 resulted higher in subjects with TAO than in healthy subjects (46.9 ± 20.23 and 41.475 ± 3.06; p = 0.01168).


Subfoveal choroidal thickness and choroidal blood flow were significantly different in patients with TAO compared with healthy subjects.

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Authors and Affiliations



Conception and design: Del Noce, Vagge. Acquisition of data: Del Noce. Analysis and interpretation of data: Del Noce, Vagge, Iester, Nicolò. Drafting the article: Del Noce, Vagge. Critically revising the article: Traverso, Iester. Reviewed the submitted version of manuscript: Del Noce, Vagge, Nicolò, Traverso. Approved the final version of the manuscript on behalf of all authors: Del Noce, Vagge. Statistical analysis: Del Noce, Traverso, Iester. Study supervision: Vagge, Traverso.

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Correspondence to Aldo Vagge.

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Del Noce, C., Vagge, A., Nicolò, M. et al. Evaluation of choroidal thickness and choroidal vascular blood flow in patients with thyroid-associated orbitopathy (TAO) using SD-OCT and Angio-OCT. Graefes Arch Clin Exp Ophthalmol 258, 1103–1107 (2020).

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