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Comparison of visual field defect progression in secondary Glaucoma due to anterior uveitis caused by three types of herpes viruses

  • Inflammatory Disorders
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Abstract

Purpose

To clarify the prevalence of secondary glaucoma (SG) and its speed of progression in patients with herpes simplex virus (HSV)-anterior uveitis (AU), varicella zoster virus (VZV)-AU, and cytomegalovirus (CMV)-AU.

Methods

In total, 170 patients with herpetic AU were enrolled in this retrospective observational case series. Patients with visual field (VF) defects and glaucomatous disc abnormalities were diagnosed with SG. Moreover, the speed of SG progression was defined as decreasing mean deviation (MD) values per year. SG prevalence and annual MD-value decrease were compared among the three types of herpetic AU.

Results

SG prevalence was 16%, 9%, and 72% in patients with HSV-AU, VZV-AU, and CMV-AU, respectively. Patients with CMV-AU had the highest SG prevalence (odds ratio = 3.15; 95% confidence interval = 1.15–8.65; P < 0.05). Furthermore, the annual MD-value change was significantly higher in SG caused by CMV-AU than in that caused by HSV/VZV-AU (−2.6 ± 2.4 dB/year and −0.45 ± 0.54 dB/year, respectively; P < 0.05).

Conclusions

Our results demonstrated that patients with CMV-AU may have a higher risk and faster speed of progression of SG than patients with HSV/VZV-AU. Therefore, clinicians should monitor glaucoma onset and VF-defect progression in patients with CMV-AU.

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Funding

This work was supported in part by a Grant-in-Aid for JSPS KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology of Japan (Grant Number JP18K09398) and a Grant-in-Aid for Research on Specific Diseases of the Health Sciences Research from the Ministry of Health, Labor and Welfare of Japan (Grant Number H29-nanti-ippan-050).

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Authors and Affiliations

  1. Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Shintaro Shirahama, Toshikatsu Kaburaki, Hisae Nakahara, Rie Tanaka, Keiko Komae & Makoto Aihara

  2. Department of Ophthalmology, Cancer Institute Hospital, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan

    Sachiko Takada

  3. Department of Ophthalmology, Tokyo Shinjuku Medical Center, 5-1 Tsukudo-cho, Shinjuku-ku, Tokyo, 162-8543, Japan

    Yujiro Fujino

  4. Department of Ophthalmology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan

    Hidetoshi Kawashima

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  1. Shintaro Shirahama
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  2. Toshikatsu Kaburaki
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Correspondence to Toshikatsu Kaburaki.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Opt-out consent was obtained from all patients. This method was used for participant recruitment in the study; information was provided to the potential participant regarding the research and their involvement and where their participation is presumed unless they decline to participate.

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Shirahama, S., Kaburaki, T., Takada, S. et al. Comparison of visual field defect progression in secondary Glaucoma due to anterior uveitis caused by three types of herpes viruses. Graefes Arch Clin Exp Ophthalmol 258, 639–645 (2020). https://doi.org/10.1007/s00417-019-04559-w

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  • DOI: https://doi.org/10.1007/s00417-019-04559-w

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