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Spontaneous regression of congenital corneal opacity

  • Cornea
  • Published:
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Abstract

Purpose

To determine the incidence of spontaneous regression of congenital corneal opacity (CCO) and identify clinical factors associated with the regression.

Methods

Medical records and anterior segment photographs were reviewed of 57 eyes in 35 patients with CCO that were not related to congenital glaucoma, tumors, infection, trauma, or metabolic disorders and were followed up without corneal transplantation for longer than one year at Seoul National University Hospital. Spontaneous regression of corneal opacity was defined as a decrease in corneal opacity significant enough for visual axis clearance. Data on demographics, systemic, and ocular characteristics were collected and compared between patients who had spontaneous regression of CCO and those who did not.

Results

Spontaneous regression of corneal opacity developed in 32 eyes (22 patients, 56.1%) out of 57 CCO eyes (35 patients) at the mean 8.2 ± 5.4 months of age (the median 6.7 months). Absence of combined ocular anomalies such as iris anomaly, lens opacity, and peripheral corneal vascularization was significantly associated with the regression of opacity.

Conclusions

Corneal opacity can spontaneously regress in 56.1% of eyes with CCO during the first year of life. Careful follow-up with amblyopia management can be one of treatment options for CCO.

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Authors and Affiliations

  1. Department of Ophthalmology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea

    Sooyeon Choe, Chang Ho Yoon, Mee Kum Kim, Young Suk Yu & Joo Youn Oh

  2. Department of Ophthalmology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Korea

    Mee Kum Kim, Joon Young Hyon, Young Suk Yu & Joo Youn Oh

  3. Department of Ophthalmology, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam, 13620, Korea

    Joon Young Hyon

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  1. Sooyeon Choe
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  2. Chang Ho Yoon
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  3. Mee Kum Kim
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Correspondence to Joo Youn Oh.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Board of Seoul National University Hospital (IRB No. H-1810-029-977) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from guardians of all individual participants included in the study.

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Choe, S., Yoon, C.H., Kim, M.K. et al. Spontaneous regression of congenital corneal opacity. Graefes Arch Clin Exp Ophthalmol 258, 359–366 (2020). https://doi.org/10.1007/s00417-019-04526-5

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  • DOI: https://doi.org/10.1007/s00417-019-04526-5

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