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The association between cone density and visual function in the macula of patients with retinitis pigmentosa

  • Tomoko Ueda-Consolvo
  • Hironori Ozaki
  • Tomoko Nakamura
  • Toshihiko Oiwake
  • Atsushi HayashiEmail author
Retinal Disorders

Abstract

Purpose

We observed cone photoreceptors by using adaptive optics (AO) fundus camera and optical coherence tomography (OCT) in patients with retinitis pigmentosa (RP) and examined the correlations between cone photoreceptors and visual function over 2 years.

Methods

Six patients with RP were studied. All patients underwent measurement using best-corrected decimal visual acuity, OCT, a Humphrey Field Analyzer with the 10-2 test grid pattern, and AO. AO images of the foveal center were obtained using an rtx1™ AO fundus camera, and cone counting was performed at 0.5 mm from the foveal center.

Results

AO detected a decrease of cone density over 2 years in RP patients. However, visual acuity, foveal sensitivity, and photoreceptor thickness were not changed over the 2 years.

Conclusions

AO images showed a decrease in the number of foveal cone densities over 2 years in patients with RP. AO may shorten the period required to predict the RP progression rate.

Keywords

Adaptive optics Cone density Foveal sensitivity Photoreceptor Retinitis pigmentosa 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures involving human participants were in accordance with the ethical standards of the institutional guidelines, the national research committee, and the 1964 Helsinki declaration.

Informed consent

Informed consent was obtained from all individual participants included in this study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Tomoko Ueda-Consolvo
    • 1
  • Hironori Ozaki
    • 1
  • Tomoko Nakamura
    • 1
  • Toshihiko Oiwake
    • 1
  • Atsushi Hayashi
    • 1
    Email author
  1. 1.Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical SciencesUniversity of ToyamaToyamaJapan

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