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Comparison of clinical characteristics in patients with Vogt-Koyanagi-Harada disease with and without anti-retinal antibodies

  • Inflammatory Disorders
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Abstract

Purpose

To compare the clinical characteristics of Vogt-Koyanagi-Harada (VKH) disease patients with and without anti-retinal antibodies (ARAs) that are frequently detected in autoimmune retinopathy.

Methods

Using immunoblot analyses, serum autoantibodies for recoverin, carbonic anhydrase II, and α-enolase were examined in 20 treatment-naïve patients with VKH disease. Clinical factors before and after systemic corticosteroid therapy, including best-corrected visual acuity (BCVA) and macular outer retinal morphology, were statistically compared between patients with VKH disease with and without ARAs.

Results

Serum ARAs were detected in 50.0% of patients with VKH disease. There were no significant differences in clinical factors between the two groups, including final BCVA, frequency of uveitis recurrence, and recovery of the macular ellipsoid zone after systemic corticosteroid therapy.

Conclusions

Our results suggest that the detected ARAs did not influence visual outcomes, the chronicity of uveitis, or outer retinal morphology in patients with VKH disease.

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References

  1. Greco A, Fusconi M, Gallo A, Turchetta R, Marinelli C, Macri GF, De Virgilio A, de Vincentiis M (2013) Vogt-Koyanagi-Harada syndrome. Autoimmun Rev 12:1033–1038

    Article  CAS  PubMed  Google Scholar 

  2. Rao NA (2007) Pathology of Vogt-Koyanagi-Harada disease. Int Ophthalmol 27:81–85

    Article  PubMed  Google Scholar 

  3. Lavezzo MM, Sakata VM, Morita C, Rodriguez EE, Abdallah SF, da Silva FT, Hirata CE, Yamamoto JH (2016) Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes. Orphanet J Rare Dis 11:29

    Article  PubMed  PubMed Central  Google Scholar 

  4. Hirooka K, Saito W, Namba K, Takemoto Y, Mizuuchi K, Uno T, Tagawa Y, Hashimoto Y, Ishida S (2013) Relationship between choroidal blood flow velocity and choroidal thickness during systemic corticosteroid therapy for Vogt-Koyanagi-Harada disease. Graefes Arch Clin Experiment Ophthalmol 253:609–617

    Article  CAS  Google Scholar 

  5. Hirooka K, Saito W, Namba K, Mizuuchi K, Iwata D, Hashimoto Y, Ishida S (2017) Early post-treatment choroidal thickness to alert sunset glow fundus in patients with Vogt-Koyanagi-Harada disease treated with systemic corticosteroids. PLoS One 12:e0172612

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Sakamoto T, Murata T, Inomata H (1991) Class II major histocompatibility complex on melanocytes of Vogt-Koyanagi-Harada disease. Arch Ophthalmol 109:1270–1274

    Article  CAS  PubMed  Google Scholar 

  7. Yamaki K, Gocho K, Hayakawa K, Kondo I, Sakuragi S (2000) Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease. J Immunol 165:7323–7329

    Article  CAS  PubMed  Google Scholar 

  8. Sugita S, Takase H, Taguchi C, Imai Y, Kamoi K, Kawaguchi T, Sugamoto Y, Futagami Y, Itoh K, Mochizuki M (2006) Ocular infiltrating CD4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens. Invest Ophthalmol Vis Sci 47:2547–2554

    Article  PubMed  Google Scholar 

  9. Sugita S, Takase H, Kawaguchi T, Taguchi C, Mochizuki M (2007) Cross-reaction between tyrosinase peptides and cytomegalovirus antigen by T cells from patients with Vogt-Koyanagi-Harada disease. Int Ophthalmol 27:87–95

    Article  PubMed  Google Scholar 

  10. Perry HD, Font RL (1977) Clinical and histopathologic observations in severe Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol 83:242–254

    Article  CAS  PubMed  Google Scholar 

  11. Chan CC, Palestine AG, Nussenblatt RB, Roberge FG, Benezra D (1985) Anti-retinal auto-antibodies in Vogt-Koyanagi-Harada syndrome, Behcet's disease, and sympathetic ophthalmia. Ophthalmology 92:1025–1028

    Article  CAS  PubMed  Google Scholar 

  12. Ten Berge JC, Schreurs MW, Vermeer J, Meester-Smoor MA, Rothova A (2016) Prevalence and clinical impact of antiretinal antibodies in uveitis. Acta Ophthalmol 94:282–288

    Article  CAS  PubMed  Google Scholar 

  13. Ten Berge JC, van Rosmalen J, Vermeer J, Hellström C, Lindskog C, Nilsson P, Qundos U, Rothova A, Schreurs MW (2016) Serum autoantibody profiling of patients with paraneoplastic and non-paraneoplastic autoimmune retinopathy. PLoS One 11:e0167909

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Adamus G, Machnicki M, Seigel GM (1997) Apoptotic retinal cell death induced by antirecoverin autoantibodies of cancer-associated retinopathy. Invest Ophthalmol Vis Sci 38:283–291

    CAS  PubMed  Google Scholar 

  15. Heckenlively JR, Ferreyra HA (2008) Autoimmune retinopathy: a review and summary. Semin Immunopathol 30:127–134

    Article  PubMed  Google Scholar 

  16. Chan JW (2003) Paraneoplastic retinopathies and optic neuropathies. Sur Ophthalmol 48:12–38

    Article  Google Scholar 

  17. Rahimy E, Sarraf D (2013) Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: evaluation and management. Surv Ophthalmol 58:430–458

    Article  PubMed  Google Scholar 

  18. Ando R, Saito W, Kanda A, Kase S, Fujinami K, Sugahara M, Nakamura Y, Eguchi S, Mori S, Noda K, Shinoda K, Ishida S (2018) Clinical features of Japanese patients with anti-α-enolase antibody-positive autoimmune retinopathy: novel subtype of multiple drusen. Am J Ophthalmol 196:181–196

    Article  CAS  PubMed  Google Scholar 

  19. Adamus G (2009) Autoantibody targets and their cancer relationship in the pathogenicity of paraneoplastic retinopathy. Autoimmun Rev 8:410–414

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Adamus G, Aptsiauri N, Guy J, Heckenlively J, Flannery J, Hargrave PA (1996) The occurrence of serum autoantibodies against enolase in cancer-associated retinopathy. Clin Immunol Immunopathol 78:120–129

    Article  CAS  PubMed  Google Scholar 

  21. Ren G, Adamus G (2004) Cellular targets of anti-a-enolase autoantibodies of patients with autoimmune retinopathy. J Autoimmun 23:161–167

    Article  CAS  PubMed  Google Scholar 

  22. Adamus G, Webb S, Shiraga S, Duvoisin RM (2006) Anti-recoverin antibodies induce an increase in intracellular calcium, leading to apoptosis in retinal cells. J Autoimmun 26:146–153

    Article  CAS  PubMed  Google Scholar 

  23. Sugiura S (1978) Vogt-Koyanagi-Harada disease. Jpn J Ophthalmol 22:9–35

    Google Scholar 

  24. Read RW, Holland GN, Rao NA, Tabbara KF, Ohno S, Arellanes-Garcia L, Pivetti-Pezzi P, Tessler HH, Usui M (2001) Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature. Am J Ophthalmol 131:647–652

    Article  CAS  PubMed  Google Scholar 

  25. Tagawa Y, Namba K, Mizuuchi K, Takemoto Y, Iwata D, Uno T, Fukuhara T, Hirooka K, Kitaichi N, Ohno S, Ishida S (2016) Choroidal thickening prior to anterior recurrence in patients with Vogt-Koyanagi-Harada disease. Br J Ophthalmol 100:473–477

    Article  PubMed  Google Scholar 

  26. Takemoto Y, Namba K, Mizuuchi K, Iwata D, Uno T, Ohno S, Hirooka K, Hashimoto Y, Saito W, Sugiyama K, Ishida S (2016) Choroidal circulation impairment during the anterior recurrence of Vogt-Koyanagi-Harada disease confirmed with indocyanine green angiography and laser speckle flowgraphy. Acta Ophthalmol 94:e629–e636

    Article  PubMed  Google Scholar 

  27. Saito M, Saito W, Kanda A, Ohguro H, Ishida S (2014) A case of paraneoplastic optic neuropathy and outer retinitis positive for autoantibodies against collapsin response mediator protein-5, recoverin, and α-enolase. BMC Ophthalmol 14:5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Adamus G, Amundson D, Seigel GM, Machnicki M (1998) Anti-enolase-alpha autoantibodies in cancer-associated retinopathy: epitope mapping and cytotoxicity on retinal cells. J Autoimmun 11:671–677

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We thank Mrs. Ikuyo Hirose (Hokkaido University) for her technical assistance.

Funding

No funding was received for this research.

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Nishi 7, Kita 15, Kita-ku, Sapporo, 060-8638, Japan

    Yuki Hashimoto, Wataru Saito, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Kousuke Noda, Atsuhiro Kanda & Susumu Ishida

  2. Kaimeido Eye and Dental Clinic, Sapporo, Japan

    Wataru Saito

Authors
  1. Yuki Hashimoto
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  2. Wataru Saito
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  3. Kenichi Namba
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  4. Kazuomi Mizuuchi
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  6. Kousuke Noda
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Correspondence to Wataru Saito.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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The current study was approved by the ethics committee of Hokkaido University Hospital (#015-0376).

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Hashimoto, Y., Saito, W., Namba, K. et al. Comparison of clinical characteristics in patients with Vogt-Koyanagi-Harada disease with and without anti-retinal antibodies. Graefes Arch Clin Exp Ophthalmol 257, 1751–1758 (2019). https://doi.org/10.1007/s00417-019-04330-1

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  • DOI: https://doi.org/10.1007/s00417-019-04330-1

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