A novel strategy for quantification of panoramic en face optical coherence tomography angiography scan field
To compare the retinal area measured on a panoramic en face optical coherence tomography angiography (OCTA) image with that on an ultra-widefield fluorescein angiography (UWF FA) image.
Sixteen eyes (11 with branch retinal vein occlusion, 2 with central retinal vein occlusion, 1 with branch retinal artery occlusion, and 2 with hypertensive retinopathy) were included in this study. A panoramic en face OCTA image was created from five single non-panoramic en face OCTA 12 × 12-mm images. The panoramic OCTA image was superimposed on the corresponding UWF FA image after image registration; the total retinal area was measured using the grid displayed on the UWF FA image. The area on the UWF FA image was measured using stereographic projection software.
The area of retina measured on a single non-panoramic 12 × 12-mm en face OCTA image, a panoramic en face OCTA image, and a UWF FA image was 152.4 ± 3.4 mm2, 369.6 ± 26.9 mm2, and 813.1 ± 24.4 mm2, respectively (P < 0.0001). The panoramic OCTA image was 2.42-fold larger than a single non-panoramic 12 × 12-mm OCTA image and 0.46-fold smaller than a UWF FA image.
Grid-based measurements using an OCTA image superimposed on the UWF FA image enabled measurement on the panoramic en face OCTA image with minimum influence of magnification errors because of the curved surface of the retina.
KeywordsOptical coherence tomography angiography Ultra-widefield Panoramic Fluorescein angiography
Compliance with ethical standards
Conflicts of interest
Shin Kadomoto, None; Akihito Uji, Alcon (R), Senju (R), Canon (R); Yuki Muraoka, Bayer (R), Novartis Pharma K.K. (R), Senju (R), Nidek (R); Tadamichi Akagi, Alcon (R), Kowa (R), Pfizer (R), Santen (R), Senju (R), Canon (R); Manabu Miyata, Alcon (R), Santen (R); Akitaka Tsujikawa, Pfizer (F, R), Novartis Pharma K.K. (F, R), Bayer (F, R), Alcon (F, R), Santen (F, R), Senju (F, R), Nidek (R), Kowa (F, R), Hoya (F, R), AMO Japan (F, R).
All procedures were performed in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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