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Clinical characteristics of pachydrusen in central serous chorioretinopathy

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To evaluate the clinical characteristics of pachydrusen in central serous chorioretinopathy (CSC) and investigate the relationship between choroidal circulation and pachydrusen.

Methods

In a retrospective case series of 302 eyes of 151 patients with treatment-naïve CSC, we assessed the incidence of pachydrusen and their features on indocyanine green angiography (ICGA) and optical coherence tomography (OCT).

Results

Pachydrusen were observed in 82 of the 302 eyes (27.2%). The patients with pachydrusen were significantly older than those without pachydrusen. In 36 of the 82 eyes with pachydrusen, the choriocapillaris perfusion phase of ICGA was recorded. Pachydrusen were localized within the geographic filling delay of the choriocapillaris in 26 of the 36 eyes (72.2%). In the late phase of ICGA, pachydrusen corresponded to punctate hyperfluorescent spots in 69 of the 82 eyes (84.1%) and localized within sites of choroidal vascular hyperpermeability in 45 eyes (54.9%). En face OCT revealed pachydrusen to be localized over the dilated outer choroidal vessels in 70 of the 82 eyes (85.4%). B-mode OCT showed pachydrusen under the retinal pigment epithelium (RPE) in 72 of the 82 eyes (87.8%). There was no significant difference in central choroidal thickness between eyes with and without pachydrusen.

Conclusions

Pachydrusen in patients with CSC were frequently localized within the choriocapillaris filling delay and over the dilated outer choroidal vessels. Moreover, they were frequently observed under the RPE and corresponded to punctate hyperfluorescent spots on ICGA. These findings suggest that inner choroidal circulation impairment due to dilatation of outer choroidal vessels might induce pachydrusen.

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References

  1. Imamura Y, Fujiwara T, Margolis R, Spaide RF (2009) Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy. Retina 29:1469–1473. https://doi.org/10.1097/IAE.0b013e3181be0a83

    Article  PubMed  Google Scholar 

  2. Warrow DJ, Hoang QV, Freund KB (2013) Pachychoroid pigment epitheliopathy. Retina 33:1659–1672. https://doi.org/10.1097/IAE.0b013e3182953df4

    Article  PubMed  Google Scholar 

  3. Pang CE, Freund KB (2015) Pachychoroid neovasculopathy. Retina 35:1–9. https://doi.org/10.1097/IAE.0000000000000331

    Article  CAS  PubMed  Google Scholar 

  4. Gallego-Pinazo R, Dolz-Marco R, Gomez-Ulla F, Mrejen S, Freund KB (2014) Pachychoroid diseases of the macula. Med Hypothesis Discov Innov Ophthalmol 3:111–115

    PubMed  PubMed Central  Google Scholar 

  5. Miyake M, Ooto S, Yamashiro K, Takahashi A, Yoshikawa M, Akagi-Kurashige Y, Ueda-Arakawa N, Oishi A, Nakanishi H, Tamura H, Tsujikawa A, Yoshimura N (2015) Pachychoroid neovasculopathy and age-related macular degeneration. Sci Rep 5:16204. https://doi.org/10.1038/srep16204

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Takahashi A, Ooto S, Yamashiro K, Tamura H, Oishi A, Miyata M, Hata M, Yoshikawa M, Yoshimura N, Tsujikawa A (2017) Pachychoroid geographic atrophy. Ophthalmology Retina 2:295–305

    Article  PubMed  Google Scholar 

  7. Age-Related Eye Disease Study Research G (2001) The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study report number 6. Am J Ophthalmol 132:668–681

    Article  Google Scholar 

  8. Spaide RF (2018) Disease expression in nonexudative age-related macular degeneration varies with choroidal thickness. Retina 38:708–716. https://doi.org/10.1097/IAE.0000000000001689

    Article  PubMed  Google Scholar 

  9. Baek J, Lee JH, Chung BJ, Lee K, Lee WK (2018) Choroidal morphology under pachydrusen. Clin Exp Ophthalmol. https://doi.org/10.1111/ceo.13438

  10. Scheider A, Nasemann JE, Lund OE (1993) Fluorescein and indocyanine green angiographies of central serous choroidopathy by scanning laser ophthalmoscopy. Am J Ophthalmol 115:50–56

    Article  CAS  PubMed  Google Scholar 

  11. Prunte C, Flammer J (1996) Choroidal capillary and venous congestion in central serous chorioretinopathy. Am J Ophthalmol 121:26–34

    Article  CAS  PubMed  Google Scholar 

  12. Iida T, Kishi S, Hagimura N, Shimizu K (1999) Persistent and bilateral choroidal vascular abnormalities in central serous chorioretinopathy. Retina 19:508–512

    Article  CAS  PubMed  Google Scholar 

  13. Pang CE, Shah VP, Sarraf D, Freund KB (2014) Ultra-widefield imaging with autofluorescence and indocyanine green angiography in central serous chorioretinopathy. Am J Ophthalmol 158:362–371 e362. https://doi.org/10.1016/j.ajo.2014.04.021

    Article  PubMed  Google Scholar 

  14. Dansingani KK, Balaratnasingam C, Naysan J, Freund KB (2016) En face imaging of pachychoroid spectrum disorders with swept-source optical coherence tomography. Retina 36:499–516. https://doi.org/10.1097/IAE.0000000000000742

    Article  PubMed  Google Scholar 

  15. Hiroe T, Kishi S (2018) Dilatation of asymmetric vortex vein in central serous chorioretinopathy. Ophthalmol Retina 2:152–161

    Article  PubMed  Google Scholar 

  16. Kishi S, Matsumoto H, Sonoda S, Hiroe T, Sakamoto T, Akiyama H (2018) Geographic filling delay of the choriocapillaris in the region of dilated asymmetric vortex veins in central serous chorioretinopathy. PLoS One 13:e0206646. https://doi.org/10.1371/journal.pone.0206646

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakagawa S, Yoshimura N (2010) Punctate hyperfluorescent spots associated with central serous chorioretinopathy as seen on indocyanine green angiography. Retina 30:801–809. https://doi.org/10.1097/IAE.0b013e3181c72068

    Article  PubMed  Google Scholar 

  18. Lee WK, Baek J, Dansingani KK, Lee JH, Freund KB (2016) Choroidal morphology in eyes with polypoidal choroidal vasculopathy and normal or subnormal subfoveal choroidal thickness. Retina 36(Suppl 1):S73–S82. https://doi.org/10.1097/IAE.0000000000001346

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Gunma University, School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan

    Hidetaka Matsumoto, Ryo Mukai, Masahiro Morimoto, Shunsuke Tokui, Shoji Kishi & Hideo Akiyama

Authors
  1. Hidetaka Matsumoto
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  2. Ryo Mukai
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  3. Masahiro Morimoto
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  4. Shunsuke Tokui
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  5. Shoji Kishi
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  6. Hideo Akiyama
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Contributions

Involved in design and conduct of the study (H.M., R.M.); collection of the data (H.M., M.M., S.T.); management (H.M.); analysis (H.M., R.M.); interpretation (H.M.); preparation of article (H.M.); review and approval of the manuscript (R.M., K.S., H.A.).

Corresponding author

Correspondence to Hidetaka Matsumoto.

Ethics declarations

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

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Matsumoto, H., Mukai, R., Morimoto, M. et al. Clinical characteristics of pachydrusen in central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 257, 1127–1132 (2019). https://doi.org/10.1007/s00417-019-04284-4

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  • DOI: https://doi.org/10.1007/s00417-019-04284-4

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