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Correlation between B-scan optical coherence tomography, en face thickness map ring and hyperautofluorescent ring in retinitis pigmentosa patients

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Objective

To evaluate and compare the B-scan OCT loss of ellipsoid zone, OCT en face thickness map constriction, and hyperautofluorescent ring constriction in RP patients.

Methods

Retrospective case series study. Forty-eight eyes of 24 RP patients with a parafoveal hyperautofluorescent ring were studied. The diagnosis of RP was established by the presence of rod response impairment and a prevalent decrease of scotopic over photopic responses on electroretinography. The FAF and spectral-domain optical coherence tomography (SD-OCT) images were obtained from 24 patients with RP. The measurements of the EZ line width on B-scan OCT, hyperautofluorescent ring area on FAF, and hyperautofluorescent ring area on en face thickness map were performed by two independent graders. The measurements of these three parameters were correlated.

Results

The mean age of study patients was 46 years old (sd = 19). The external and internal FAF rings involving the fovea were identified in all study eyes. The area of the thickness ring decreased at an average rate of 0.5 (sd 0.4) mm2 per year (P < 0.001). The average rate of EZ-line constriction was estimated to be 123 (sd 63) μm per year (P < 0.001). The hyperautofluorescent ring area decreased at an average rate of 0.9 (sd 0.98) mm2 per year (P < 0.001). The strongest correlation was observed between hyperautofluorescent ring area and EZ-line width (r = 0.78).

Conclusions

We observed that the hyperautofluorescent ring area exhibits a faster progression rate than the area of the thickness ring. In addition, we found that the EZ-line width had a high positive correlation with the hyperautofluorescent ring area and a moderate positive correlation with area of the thickness ring.

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Funding

Jonas Children’s Vision Care is supported by the National Institute of Health [R24 EY027285, 5P30EY019007, R01EY018213, R01EY024698, R01EY026682, R21AG050437], National Cancer Institute Core [5P30CA013696], the Schneeweiss Stem Cell Fund, New York State [SDHDOH01-C32590GG-3450000], the Foundation Fighting Blindness New York Regional Research Center Grant [C-NY05-0705-0312].

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Authors and Affiliations

  1. Department of Ophthalmology, Columbia University, New York, NY, USA

    Vitor K. L. Takahashi, Júlia T. Takiuti, Ruben Jauregui, Christine L. Xu & Stephen H. Tsang

  2. Jonas Children’s Vision Care and Bernard and Shirlee Brown Glaucoma Laboratory, New York, USA

    Vitor K. L. Takahashi, Júlia T. Takiuti, Ruben Jauregui, Christine L. Xu & Stephen H. Tsang

  3. Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil

    Vitor K. L. Takahashi & Luiz H. Lima

  4. Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil

    Júlia T. Takiuti

  5. Weill Cornell Medical College, New York, USA

    Ruben Jauregui

  6. Department of Biostatistics, Columbia University, New York, NY, USA

    Jimmy K. Duong

  7. Department of Pathology and Cell Biology, Stem Cell Initiative (CSCI), Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY, USA

    Stephen H. Tsang

  8. Harkness Eye Institute, Columbia University Medical Center, 635 West 165th Street, Box 212, New York, NY, 10032, USA

    Stephen H. Tsang

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  1. Vitor K. L. Takahashi
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  7. Stephen H. Tsang
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Corresponding author

Correspondence to Stephen H. Tsang.

Ethics declarations

Informed consent was obtained from all study patients as outlined by the protocol #AAAR0284 approved by the Institutional Review Board at Columbia University Medical Center. This study adhered to the tenets of the Declaration of Helsinki, and none of the study data, including imaging and genetic testing results, are identifiable to individual patients.

Competing interest

The authors declare that they have no competing interest.

Ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Takahashi, V.K.L., Takiuti, J.T., Jauregui, R. et al. Correlation between B-scan optical coherence tomography, en face thickness map ring and hyperautofluorescent ring in retinitis pigmentosa patients. Graefes Arch Clin Exp Ophthalmol 257, 1601–1609 (2019). https://doi.org/10.1007/s00417-019-04265-7

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  • DOI: https://doi.org/10.1007/s00417-019-04265-7

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