Skip to main content

Advertisement

SpringerLink
Log in

Involvement of circulatory disturbance in optic disk melanocytoma with visual dysfunction

  • Oncology
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

This study aims to examine the relationship between ocular circulation changes and visual field defects in optic disk melanocytoma (ODM).

Methods

Five eyes of five patients were enrolled in this study. All patients were diagnosed with ODM in the Department of Ophthalmology, Hokkaido University Hospital from March 2009 to November 2017. Ophthalmological data including optical coherence tomography angiography (OCTA) and laser speckle flowgraphy (LSFG) findings were retrospectively analyzed.

Results

The five ODM cases consisted of two females and three males. Ages of the patients ranged from 47 to 82 years (mean 54 years). Follow-up periods were from 4 to 105 months. Fluorescein angiography showed hypo-fluorescence throughout the examination in all four eyes examined with this modality. OCTA detected dense blood vessel networks in the tumor in two out of the five eyes. Nasal visual field defects were found in two other eyes, which were correlated with locations of tumors free of vessel networks. One ODM eye without marked visual field defects and pigmentations showed lower mean blur rates determined by LSFG in optic disk vessels and tissue circulations than those in the contralateral eye. During follow-up, there was no tumor enlargement in any case.

Conclusions

This study showed the relationship between the deficit of blood vessel networks and visual field defects in ODM patients. LSFG demonstrated reduced blood flow in the tumor, suggesting that circulatory disorder caused by the optic disk tumor might be correlated with visual field defect.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Zimmerman LE, Garron LK (1962) Melanocytoma of the optic disk. Int Ophthalmol Clin 2:431–440

    Article  Google Scholar 

  2. Shields JA, Demirci H, Mashayekhi A, Shields CL (2004) Melanocytoma of optic disc in 115 cases: the 2004 Samuel Johnson memorial lecture, part 1. Ophthalmology 111:1739–1746

    PubMed  Google Scholar 

  3. Salinas-La Rosa CM (2017) Malignant transformation of optic nerve Melanocytoma into melanoma associated with ocular ischemic syndrome and Oculocardiac reflex: case report and review of the literature. Semin Ophthalmol 32:253–256

    Article  PubMed  Google Scholar 

  4. Cennamo G, Romano MR, Breve MA, Velotti N, Reibaldi M, de Crecchio G, Cennamo G (2017) Evaluation of choroidal tumors with optical coherence tomography: enhanced depth imaging and OCT-angiography features. Eye (Lond) 31:906–915

    Article  CAS  Google Scholar 

  5. Carnevali A, Querques L, Zucchiatti I, Scorcia V, Bandello F, Querques G (2017) Optical coherence tomography angiography features in Melanocytoma of the optic nerve. Ophthalmic Surg Lasers Imaging Retina 48:364–366

    Article  PubMed  Google Scholar 

  6. Kita Y, Hollό G, Murai A, Kita R, Hirakata A (2018) Optical coherence tomography angiography findings of an optic disc melanocytoma in a glaucoma eye. Int Ophthalmol. https://doi.org/10.1007/s10792-018-0839-9

  7. Yaoeda K, Shirakashi M, Funaki S, Funaki H, Nakatsue T, Abe H (2000) Measurement of microcirculation in the optic nerve head by laser speckle flowgraphy and scanning laser Doppler flowmetry. Am J Ophthalmol 129:734–739

    Article  CAS  PubMed  Google Scholar 

  8. Hirooka K, Saito W, Namba K, Takemoto Y, Mizuuchi K, Uno T, Tagawa Y, Hashimoto Y, Ishida S (2015) Relationship between choroidal blood flow velocity and choroidal thickness during systemic corticosteroid therapy for Vogt-Koyanagi-Harada disease. Graefes Arch Clin Exp Ophthalmol 253:609–617

    Article  CAS  PubMed  Google Scholar 

  9. Lee CS, Bae JH, Jeon IH, Byeon SH, Koh HJ, Lee SC (2010) Melanocytoma of the optic disk in the Korean population. Retina 30:1714–1720

    Article  PubMed  Google Scholar 

  10. Mueller JA, Bartsch DU, Schaller U, Freeman WR, Kampik A (2001) Imaging the microcirculation of untreated and treated human choroidal melanomas. Int Ophthalmol 23:385–393

    Article  CAS  PubMed  Google Scholar 

  11. Sallet G, Amoaku WM, Lafaut BA, Brabant P, De Laey JJ (1995) Indocyanine green angiography of choroidal tumors. Graefes Arch Clin Exp Ophthalmol 233:677–689

    Article  CAS  PubMed  Google Scholar 

  12. Papetti M, Herman IM (2002) Mechanisms of normal and tumor-derived angiogenesis. Am J Physiol Cell Physiol 282:C947–C970

    Article  CAS  PubMed  Google Scholar 

  13. Toledo JJ, Asencio-Duran M, García-Martinez JR, López-Gaona A (2017) Use of OCT angiography in choroidal melanocytic tumors. J Ophthalmol. https://doi.org/10.1155/2017/1573154

  14. Ghassemi F, Mirshahi R, Fadakar K, Sabour S (2018) Optical coherence tomography angiography in choroidal melanoma and nevus. Clin Ophthalmol 12:207–214

    Article  PubMed  PubMed Central  Google Scholar 

  15. Osher RH, Shields JA, Layman PR (1979) Pupillary and visual field evaluation in patients with melanocytoma of the optic disc. Arch Ophthalmol 97:1096–1099

    Article  CAS  PubMed  Google Scholar 

  16. Usui T, Shirakashi M, Kurosawa A, Abe H, Iwata K (1990) Visual disturbance in patients with melanocytoma of the optic disk. Ophthalmologica 201:92–98

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

No funding was received for this research.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan

    Iku Kikuchi, Satoru Kase, Yuki Hashimoto, Kiriko Hirooka & Susumu Ishida

Authors
  1. Iku Kikuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Satoru Kase
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yuki Hashimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kiriko Hirooka
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Susumu Ishida
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Satoru Kase.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

For this type of study, formal consent is not required.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kikuchi, I., Kase, S., Hashimoto, Y. et al. Involvement of circulatory disturbance in optic disk melanocytoma with visual dysfunction. Graefes Arch Clin Exp Ophthalmol 257, 835–841 (2019). https://doi.org/10.1007/s00417-019-04257-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-019-04257-7

Keywords

Search

Navigation