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An investigation on optic nerve head involvement in Fuchs uveitis syndrome using optical coherence tomography and fluorescein angiography

  • Inflammatory Disorders
  • Published:
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Abstract

Purpose

To investigate optic nerve head involvement in patients with Fuchs uveitis syndrome (FUS).

Methods

Optic nerve head of 43 FUS eyes without clinical optic disc edema and 37 unaffected fellow eyes were evaluated using optical coherence tomography (OCT) of peripapillary retina and retinal nerve fiber layer (RNFL) and fundus fluorescein angiography.

Results

Seventy-one percent of FUS eyes showed optic nerve head hyperfluorescence. The mean average RNFL thickness in FUS eyes was 115.0 ± 11.9 μm, which was thicker than unaffected eyes (103.0 ± 10.7 μm, p < 0.001). Mean average of peripapillary retinal thicknesses in FUS eyes was also greater than unaffected eyes (p < 0.001). In addition, RNFL and peripapillary retinal thicknesses in FUS eyes without optic nerve hyperfluorescence were thicker than unaffected eyes (all p = < 0.001).

Conclusions

OCT demonstrates peripapillary total retinal and nerve fiber layer thickening in FUS eyes without clinical swelling of optic disc that is not always associated with optic nerve head leakage.

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Acknowledgments

The authors would like to thank Ms. Malihe Sabeti for her technical assistance in data collection.

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Authors and Affiliations

  1. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Square, Tehran, 13352, Iran

    Mohammad Zarei, Ali Abdollahi, Sahel Darabeigi, Nazanin Ebrahimiadib, Ramak Roohipoor, Hamed Ghassemi & Masoud Aghsaei Fard

  2. Amiralmomeni Hospital, Rasht University of Medical Science, Rasht, Iran

    Reza Soltani Moghaddam

Authors
  1. Mohammad Zarei
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  2. Ali Abdollahi
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  3. Sahel Darabeigi
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  4. Nazanin Ebrahimiadib
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  5. Ramak Roohipoor
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  6. Hamed Ghassemi
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  7. Reza Soltani Moghaddam
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  8. Masoud Aghsaei Fard
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Corresponding author

Correspondence to Masoud Aghsaei Fard.

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Authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Zarei, M., Abdollahi, A., Darabeigi, S. et al. An investigation on optic nerve head involvement in Fuchs uveitis syndrome using optical coherence tomography and fluorescein angiography. Graefes Arch Clin Exp Ophthalmol 256, 2421–2427 (2018). https://doi.org/10.1007/s00417-018-4125-3

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  • DOI: https://doi.org/10.1007/s00417-018-4125-3

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