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Application of autologous serum eye drops after pterygium surgery: a prospective study

  • Cornea
  • Published:
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Abstract

Purpose

The study aims to determine the effect of 50% autologous serum drops (ASD) on corneal healing and patient comfort following pterygium surgery.

Methods

Fifty eyes of 50 patients who underwent pterygium excision combined with autologous conjunctival graft were included in this prospective randomized study: in 25 eyes, 50% ASD. In the remaining 25 eyes, conventional artificial tears (CAT) were applied postoperatively until corneal epithelium had completely epithelialized. Corneal epithelium healing speed, visual analog scale (VAS) for postoperative pain assessment, conjunctival inflammation, and recurrences were evaluated. Patients were followed up for 6 months.

Results

Mean corneal epithelium closure time was 3.16 ± 0.37 days (range 3 and 4 days) in ASD group and 4.96 ± 0.84 days in CAT group (range 4 and 6 days), and the difference was statistically significant (p < 0.001). VAS scores were significantly lower in ASD group than CAT group in the first 5 days after surgery. In 9 of 50 eyes, moderate conjunctival inflammation continued 1 month: 4 (16%) in ASD group and 5 (20%) in CAT group (p = 0.713). In total, pterygium recurrence was seen in 5 (10%) eyes: 2 eyes (8%) in ASD group and 3 eyes (12%) in CAT group (p = 0.637).

Conclusion

ASD accelerated corneal epithelial healing following pterygium surgery. ASD group had lesser pain that was seem to be related with accelerated corneal epithelial healing.

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References

  1. Akarsu C, Taner P, Ergin A (2003) Fluorouracil as chemoadjuvant for primary pterygium surgery preliminary report. Cornea 22(6):522–526

    Article  PubMed  Google Scholar 

  2. Wishaw K, Billington D, O’Brien D, Davies P (2000) The use of orbital morphine for postoperative analgesia in pterygium surgery. Anaesth Intensive Care 28(1):43–45

    PubMed  CAS  Google Scholar 

  3. Brilakis HS, Deutsch TA (2000) Topical tetracaine with bandage soft contact lens pain control after photorefractive keratectomy. J Refract Surg 16(4):444–447

    PubMed  CAS  Google Scholar 

  4. Oksuz H, Tamer C (2006) Pain relief after pterygium surgery with viscous lidocain. Ophthalmologica 220(5):323–326

    Article  PubMed  CAS  Google Scholar 

  5. Ozcimen M, Sakarya Y, Goktas S et al (2015) Effect of nepafenac eye drops on pain associated with pterygium surgery. Eye Contact Lens 41(3):187–189

    Article  PubMed  Google Scholar 

  6. Shortt AJ, Allan BD, Evans JR (2013) Laser-assisted in-situ keratomileusis (LASIK) versus photorefractive keratectomy (PRK) for myopia Cochrane database. Syst rev 31(1):CD005135

    Google Scholar 

  7. Daglıoglu MC, Coşkun M, Ilhan N et al (2014) The effects of soft contact lens use on cornea and patient’s recoveryafter autograft pterygium surgery. Cont Lens Anterior Eye 37(3):175–177

    Article  PubMed  Google Scholar 

  8. Tsubota K, Goto E, Fujita H et al (1999) Treatment of dry eye by autologous serum application in Sjogren's syndrome. Br J Ophthalmol 83(4):390–395

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Tsubota K, Goto E, Shimmura S et al (1989) Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmology 106(10):1984–1989

    Article  Google Scholar 

  10. Chen Y, Hu F, Huang J et al (2010) The effect of topical autologous serum on graft re-epithelialization after penetrating keratoplasty. Am J Ophthalmol 150(3):352–359

    Article  PubMed  Google Scholar 

  11. Schulze D, Sekundo W, Kroll P (2006) Autologous serum for the treatment of corneal epithelial abrasions in diabetic patients undergoing vitrectomy. Am J Ophthalmol 142(2):207–211

    Article  PubMed  Google Scholar 

  12. Hondur AM, Akcam T, Karaca EE, Yazici Eroglu H, Aydin B (2016) Autologous serum eye drops accelerate epithelial healing after LASEK. Curr Eye Res 41(1):15–19

    Article  PubMed  CAS  Google Scholar 

  13. Barequet IS, Soriano ES, Green WR, O’Brien TP (1999) Provision of anaesthesia with a single application of lidocaine 2% gel. J Cataract Refract Surg 25:626–631

    Article  PubMed  CAS  Google Scholar 

  14. Kheirkhah A, Casas V, Sheha H, Raju VK, Tseng SC (2008) Role of conjunctival inflammation in surgical outcome after amniotic membrane transplantation with or without fibrin glue for pterygium. Cornea 27(1):56–63

    Article  PubMed  Google Scholar 

  15. Hirst LW (2003) The treatment of pterygium. Surv Ophthalmol 48(2):145–180

    Article  PubMed  Google Scholar 

  16. Ang LP, Chua JL, Tan DT (2007) Current concepts and techniques in pterygium treatment. Curr Opin Ophthalmol 18(4):308–313

    Article  PubMed  Google Scholar 

  17. Azari AA, Rapuano CJ (2015) Autologous serum eye drops for the treatment of ocular surface disease. Eye Contact Lens 41(3):133–140

    Article  PubMed  Google Scholar 

  18. Welder JD, Bakhtiari P, Djalilian AR (2011) Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. Case Rep Ophthalmol Med 2011:576521

    PubMed  PubMed Central  Google Scholar 

  19. Pflugfelder SC, Corrales RM, de Paiva CS (2013) T helper cytokines in dry eye disease. Exp Eye Res 117:118–125.19

    Article  PubMed  CAS  Google Scholar 

  20. Pastor-Vivas AI, Alejandre-Alba N, García-Vega MI, Ariño-Gutiérrez M, García-Sandoval B, Jiménez-Alfaro I (2011) Quantifying and classifying postsurgical pain in pterygium surgery with conjunctival autografts. Arch Soc Esp Oftalmol 86(6):176–179

    Article  PubMed  CAS  Google Scholar 

  21. Peyman GA, Rahimy MH, Fernandes ML (1994) Effects of morphine on corneal sensitivity and epithelial wound healing: implications for topical ophthalmic analgesia. Br J Ophthalmol 78(2):138–141

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  22. Padda GS, Cruz OA, Krock JL (1997) Comparison of postoperative emesis, recovery profile and analgesia in pediatric strabismus repair. Ophthalmology 104(3):419–424

    Article  PubMed  CAS  Google Scholar 

  23. Caldwell M, Reilly C (2008) Effects of topical nepafenac on corneal epithelial healing time and postoperative pain after PRK: a bilateral, prospective, randomized, masked trial. J Refract Surg 24(4):377–382

    PubMed  Google Scholar 

  24. Flach AJ (2000) Topically applied non-steroidal anti-inflammatory drugs and corneal problems: an interim review and comment. Ophthalmology 107(7):1224–1226

    Article  PubMed  CAS  Google Scholar 

  25. Machkie IA (1971) Localized corneal drying in association with dellen, pterygia and related lesions. Trans Ophthalmol Soc UK 91:129–145

    Google Scholar 

  26. Hondur A, Bilgihan K, Cirak MY, Dogan O, Erdinc A, Hasanreisoglu B (2008) Microbiologic study of soft contact lenses after laser subepithelial keratectomy for myopia. Eye Contact Lens 34(1):24–27

    Article  PubMed  Google Scholar 

  27. Ohashi Y, Motokura M, Kinoshita Y, Mano T, Watanebe H, Kinoshita S et al (1989) Presence of epidermal growth factor in human tears. Invest Ophthalmol Vis Sci 30(8):1879–1882

    PubMed  CAS  Google Scholar 

  28. Gupta A, Monroy D, Ji Z, Yoshino K, Huang A, Pflugfelder SC (1996) Transforming growth factor beta-1 and beta-2 in human tear fluid. Curr Eye Res 15(6):605–614

    Article  PubMed  CAS  Google Scholar 

  29. Nelson JD, Gordon JF (1992) Topical fibronectin in the treatment of keratoconjunctivitis sicca. Chiron Keratoconjunctivitis Sicca study group. Am J Ophthalmol 114(4):441–447

    Article  PubMed  CAS  Google Scholar 

  30. Sommer A (1983) Effects of vitamin a deficiency on the ocular surface. Ophthalmology 90(6):592–600

    Article  PubMed  CAS  Google Scholar 

  31. Nakamura M, Sato N, Chikama T, Hasegawa Y, Nishida T (1997) Fibronectin facilitates corneal epithelial wound healing in diabetic rats. Exp Eye Res 64(3):355–359

    Article  PubMed  CAS  Google Scholar 

  32. Kokawa N, Sotozono C, Nishida K, Kinoshita S (1996) High total TGF-훽2 levels in normal human tears. Curr Eye Res 15(3):41–343

    Article  Google Scholar 

  33. Kojima T, Higuchi A, Goto E, Matsumoto Y, Dogru M, Tsubota K (2008) Autologous serum eye drops for the treatment of dry eye diseases. Cornea 27(Suppl 1):25–30

    Article  Google Scholar 

  34. Lambiase A, Rama P, Bonini S, Caprioglio G, Aloe L (1998) Topical treatment with nerve growth factor for corneal neurotrophic ulcers. N Engl J Med 338(17):1174–1180

    Article  PubMed  CAS  Google Scholar 

  35. Okanobo A, Chauhan SK, Dastjerdi MH, Kodati S, Dana R (2012) Efficacy of topical blockade of interleukin-1 in experimental dry eye disease. Am J Ophthalmol 154(1):63–71

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  36. Liu L, Hartwig D, Harloff S, Herminghaus P, Wedel T, Geerling G (2005) An optimised protocol for the production of autologous serum eyedrops. Graefes Arch Clin Exp Ophthalmol 243(7):706–714

    Article  PubMed  CAS  Google Scholar 

  37. Jeng BH, Dupps WJ (2009) Autologous serum 50% eyedrops in the treatment of persistent corneal epithelial defects. Cornea 28(10):1104–1108

    Article  PubMed  Google Scholar 

  38. Schrader S, Wedel T, Moll R, Geerling G (2006) Combination of serum eye drops with hydrogel bandage contact lenses in the treatment of persistent epithelial defects. Graefes Arch Clin Exp Ophthalmol 244:1345–1349

    Article  PubMed  CAS  Google Scholar 

  39. Chikama T, Wakuta M, Liu Y, Nishida T (2007) deviated mechanism of wound healing in diabetic corneas. Cornea 26:S75–S81

    Article  PubMed  Google Scholar 

  40. Borghi SM, Pinho-Riberio FA, Zarpelon AC, Cunha TM, Alves-Filho SH, Ferreria SH et al (2015) Interleukin-10 limits intense acute swimming-induced muscle mechanical hyperalgesia in mice. Exp Physiol 100(5):531–544

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Muğla Sıtkı Koçman University, 48000, Muğla, Turkey

    Sabahattin Sul, Goksu Alacamli, Pelin Ozyol & Erhan Ozyol

  2. Department of Ophthalmology, Düzce State Hospital, Düzce, Turkey

    Safak Korkmaz

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  1. Sabahattin Sul
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  2. Safak Korkmaz
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Correspondence to Sabahattin Sul.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Sul, S., Korkmaz, S., Alacamli, G. et al. Application of autologous serum eye drops after pterygium surgery: a prospective study. Graefes Arch Clin Exp Ophthalmol 256, 1939–1943 (2018). https://doi.org/10.1007/s00417-018-4068-8

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  • DOI: https://doi.org/10.1007/s00417-018-4068-8

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