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Superficial and deep retinal foveal avascular zone OCTA findings of non-infectious anterior and posterior uveitis

  • Inflammatory Disorders
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Abstract

Purpose

To compare the superficial (FAZ-S) and deep foveal avascular zones (FAZ-D) of non-infectious anterior and posterior uveitis to healthy controls, using optical coherence tomography angiography (OCTA).

Methods

OCTA was performed on 74 eyes: 34 eyes with non-infectious posterior uveitis (with (post+CME) and without macular edema (post−CME)), 11 eyes with non-infectious anterior uveitis (with (ant+CME) and without macular edema (ant−CME)), and the control group which included 29 healthy eyes.

Results

Eyes suffering from non-infectious posterior uveitis presented with significantly larger FAZ-D when compared to healthy controls, both in the presence or in the absence of macular edema (p < 0.001). In the presence of macular edema, eyes presenting with anterior uveitis (ant+CME) also showed significantly larger FAZ-S (p = 0.03) and FAZ-D (p < 0.001), when compared to healthy controls. In the absence of macular edema, eyes with anterior uveitis cannot be distinguished from controls (p > 0.6).

Conclusion

The deep retinal foveal avascular zone seems to be enlarged in eyes presenting with non-infectious posterior uveitis, both in the presence or absence of macular edema.

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Acknowledgements

We thank Dr. Andy Schoetzau for statistical advice.

Funding

The Swiss National Science Foundation (SNF) provided financial support in the form of ad personam funding under Grant number IZK0Z3_173498 for principal proposer Maria Waizel. The sponsor had no role in the design or conduct of this research.

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Authors and Affiliations

  1. Department of Ophthalmology, University Hospital Basel, Mittlere Strasse 91, CH-4031, Basel, Switzerland

    Maria Waizel & Margarita G. Todorova

  2. University of Basel, Basel, Switzerland

    Maria Waizel & Margarita G. Todorova

  3. DHU Vision and Handicaps, Pierre and Marie Curie School of Medicine, Sorbonne Universités, Paris, France

    Maria Waizel, Celine Terrada, Phuc LeHoang, Natalie Massamba & Bahram Bodaghi

Authors
  1. Maria Waizel
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  2. Margarita G. Todorova
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  3. Celine Terrada
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  4. Phuc LeHoang
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  5. Natalie Massamba
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  6. Bahram Bodaghi
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Correspondence to Maria Waizel.

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Conflict of interest

All other authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Maria Waizel and Margarita G. Todorova share same contribution.

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Waizel, M., Todorova, M.G., Terrada, C. et al. Superficial and deep retinal foveal avascular zone OCTA findings of non-infectious anterior and posterior uveitis. Graefes Arch Clin Exp Ophthalmol 256, 1977–1984 (2018). https://doi.org/10.1007/s00417-018-4057-y

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  • DOI: https://doi.org/10.1007/s00417-018-4057-y

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