Safety and efficacy of dexamethasone intravitreal implant for treatment of macular edema secondary to retinal vein occlusion in Chinese patients: randomized, sham-controlled, multicenter study
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We would like to address several challenges that arise from the study by Li et al. .
There was a selection bias attributable to encompass in the study of two completely different etiologic subgroups of patients, namely, patients older than 50 years, who usually have common systemic conditions such as hypertension and diabetes and patients younger than 50 years, where other mechanisms, such as the hyperviscosity syndrome or inflammatory condition, should be specifically considered. Likewise, the inclusion in the study of two types of retinal vein occlusions (RVOs), for example, branch RVO and central RVO, was inappropriate because they have different etiology, pathogenesis, and prognosis [2, 3, 4]. Additionally, the therapeutic decisions were at the discretion of the investigator physicians in the 13 study sites. Taken together, these findings may have confounded the results.
The following relevant data are missing from the study: the age stratification...
Compliance with ethical standards
All authors have completed and submitted the ICMJE form for disclosure of potential conflicts of interest. Both authors (D.C and M.C) were involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. The authors have full control over the primary data and they agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review their data if requested.
Conflict of interest
The authors declare that they have no conflict of interest.
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