Detailed analysis of retinal morphology in patients with diabetic macular edema (DME) randomized to ranibizumab or triamcinolone treatment
- 151 Downloads
We would like to address several challenges that have arisen from the study by Karst et al. , which are specifically summarized below.
Missing data from the article by Karst et al. 
Duration of the DME before entry into the study after diabetes onset
The proportion of the eyes considered “dry” on optical coherence tomography at the end of the study
Duration of the time period between the prior treatment with anti-VEGF agents/triamcinolone and the index date (the date of the start of the study)
The criteria used to define the clinically significant DME, if it was present in some patients
The prevalence of vitreoretinal interface abnormalities (e.g.,vitreomacular adhesion/traction and epiretinal membranes) at enrollment and at the end of the follow-up period as potential predictors influencing functional and morphologic improvements
The qualitative status of the ganglion cell complex...
All authors have completed and submitted the ICMJE form for disclosure of potential conflicts of interest. No financial disclosures. Both authors (D.C and M.C) were involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
The authors have full control over the primary data, and they agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review their data if requested.
Compliance with ethical standards
Conflict of interest
All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.
- 10.Călugăru D, Călugăru M (2017) Real-world outcomes of ranibizumab treatment for diabetic macular edema in a United Kingdom National Health Service setting. Am J Ophthalmol 174(2):175–176Google Scholar