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Fundus autofluorescence and spectral domain optical coherence tomography as predictors for long-term functional outcome in rhegmatogenous retinal detachment

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To detect pre- and postoperative retinal changes in fundus autofluorescence (AF) and spectral domain optical coherence tomography (SD-OCT) and to correlate these with functional outcome in patients with primary rhegmatogenous retinal detachment (RRD).

Methods

A prospective, 30-month study of patients operated with 25-gauge vitrectomy for primary RRD. Patients were examined preoperatively and after 6 and 30 months, using ultrawide-field AF images (UWFI) (Optos 200Tx) and SD-OCT (Topcon 3D OCT-2000) imaging.

Results

Of 84 patients (84 eyes) included at baseline, 100.0 and 86.9% were re-examined at month 6 and 30, respectively.

Preoperative findings such as macular attachment, detachment > 750 μm from foveola, lack of intraretinal separation, and subfoveal elevation ≤ 500 μm were all associated with better BCVA at months 6 and 30. Postoperative disruption of the photoreceptor layer was associated with poor BCVA at month 6 (p < 0.001) but not at month 30.

At baseline, AF-demarcation of RRD was demonstrated by a hyperfluorescent edge in 92.0% and was associated with visual impairment at months 6 (p = 0.003) and 30 (p = 0.003).

Visual outcome at month 30 was good (≤ 0.3 logMAR (≥ 20/40 Snellen)), regardless of the preoperative, macular status. However, with significantly better visual outcome in patients with macula attachments versus partly or totally macular detachments (p < 0.001).

Conclusion

Fundus AF and SD-OCT is able to identify retinal reestablishment up to 30 months after primary RRD, with good correlation to BCVA. These findings emphasize the importance of long-term studies for final visual recovery.

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References

  1. Heimann H, Bartz-Schmidt KU, Bornfeld N, Weiss C, Hilgers RD, Foerster MH (2008) Primary pars plana vitrectomy. Techniques, indications, and results. Ophthalmologe 105(1):19–26. https://doi.org/10.1007/s00347-007-1672-0

    Article  CAS  PubMed  Google Scholar 

  2. Wong CW, Wong WL, Yeo IY, Loh BK, Wong EY, Wong DW, Ong SG, Ang CL, Lee SY (2014) Trends and factors related to outcomes for primary rhegmatogenous retinal detachment surgery in a large asian tertiary eye center. Retina 34(4):684–692. https://doi.org/10.1097/IAE.0b013e3182a48900

    Article  PubMed  Google Scholar 

  3. Eibenberger K, Georgopoulos M, Rezar-Dreindl S, Schmidt-Erfurth U, Sacu S (2018) Development of surgical management in primary rhegmatogenous retinal detachment treatment from 2009 to 2015. Curr Eye Res 43(4):517–525. https://doi.org/10.1080/02713683.2018.1428996

    Article  PubMed  Google Scholar 

  4. Falkner-Radler CI, Myung JS, Moussa S, Chan RV, Smretschnig E, Kiss S, Graf A, D'Amico DJ, Binder S (2011) Trends in primary retinal detachment surgery: results of a bicenter study. Retina 31(5):928–936. https://doi.org/10.1097/IAE.0b013e3181f2a2ad

    Article  PubMed  Google Scholar 

  5. Heimann H, Bartz-Schmidt KU, Bornfeld N, Weiss C, Hilgers RD, Foerster MH (2007) Scleral buckling versus primary vitrectomy in rhegmatogenous retinal detachment: a prospective randomized multicenter clinical study. Ophthalmology 114(12):2142–2154. https://doi.org/10.1016/j.ophtha.2007.09.013

    Article  PubMed  Google Scholar 

  6. Pastor JC, Fernandez I, Rodriguez de la Rua E, Coco R, Sanabria-Ruiz Colmenares MR, Sanchez-Chicharro D, Martinho R, Ruiz Moreno JM, Garcia Arumi J, Suarez de Figueroa M, Giraldo A, Manzanas L (2008) Surgical outcomes for primary rhegmatogenous retinal detachments in phakic and pseudophakic patients: the retina 1 project—report 2. Br J Ophthalmol 92(3):378–382. https://doi.org/10.1136/bjo.2007.129437

    Article  CAS  PubMed  Google Scholar 

  7. Heimann H, Zou X, Jandeck C, Kellner U, Bechrakis NE, Kreusel KM, Helbig H, Krause L, Schuler A, Bornfeld N, Foerster MH (2006) Primary vitrectomy for rhegmatogenous retinal detachment: an analysis of 512 cases. Graefes Arch Clin Exp Ophthalmol 244(1):69–78. https://doi.org/10.1007/s00417-005-0026-3

    Article  PubMed  Google Scholar 

  8. Mitry D, Awan MA, Borooah S, Siddiqui MA, Brogan K, Fleck BW, Wright A, Campbell H, Singh J, Charteris DG, Yorston D (2012) Surgical outcome and risk stratification for primary retinal detachment repair: results from the Scottish retinal detachment study. Br J Ophthalmol 96(5):730–734. https://doi.org/10.1136/bjophthalmol-2011-300581

    Article  CAS  PubMed  Google Scholar 

  9. Park DH, Choi KS, Sun HJ, Lee SJ (2018) Factors associated with visual outcome after macula-off rhegmatogenous retinal detachment surgery. Retina 38(1):137–147. https://doi.org/10.1097/iae.0000000000001512

    Article  PubMed  Google Scholar 

  10. Abouzeid H, Wolfensberger TJ (2006) Macular recovery after retinal detachment. Acta Ophthalmol Scand 84(5):597–605. https://doi.org/10.1111/j.1600-0420.2006.00676.x

    Article  PubMed  Google Scholar 

  11. Dell'Omo R, Mura M, Lesnik Oberstein SY, Bijl H, Tan HS (2012) Early simultaneous fundus autofluorescence and optical coherence tomography features after pars plana vitrectomy for primary rhegmatogenous retinal detachment. Retina 32(4):719–728. https://doi.org/10.1097/IAE.0b013e31822c293e

    Article  PubMed  Google Scholar 

  12. Shimoda Y, Sano M, Hashimoto H, Yokota Y, Kishi S (2010) Restoration of photoreceptor outer segment after vitrectomy for retinal detachment. Am J Ophthalmol 149(2):284–290. https://doi.org/10.1016/j.ajo.2009.08.025

    Article  PubMed  Google Scholar 

  13. Sparrow JR, Boulton M (2005) RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res 80(5):595–606. https://doi.org/10.1016/j.exer.2005.01.007

    Article  CAS  PubMed  Google Scholar 

  14. Lee E, Williamson TH, Hysi P, Shunmugam M, Dogramaci M, Wong R, Laidlaw DA (2013) Macular displacement following rhegmatogenous retinal detachment repair. Br J Ophthalmol 97(10):1297–1302. https://doi.org/10.1136/bjophthalmol-2013-303637

    Article  PubMed  Google Scholar 

  15. Shiragami C, Shiraga F, Yamaji H, Fukuda K, Takagishi M, Morita M, Kishikami T (2010) Unintentional displacement of the retina after standard vitrectomy for rhegmatogenous retinal detachment. Ophthalmology 117(1):86–92.e81. https://doi.org/10.1016/j.ophtha.2009.06.025

    Article  PubMed  Google Scholar 

  16. Wickham L, Ho-Yen GO, Bunce C, Wong D, Charteris DG (2011) Surgical failure following primary retinal detachment surgery by vitrectomy: risk factors and functional outcomes. Br J Ophthalmol 95(9):1234–1238. https://doi.org/10.1136/bjo.2010.190306

    Article  PubMed  Google Scholar 

  17. Machemer R, Aaberg TM, Freeman HM, Irvine AR, Lean JS, Michels RM (1991) An updated classification of retinal detachment with proliferative vitreoretinopathy. Am J Ophthalmol 112(2):159–165

    Article  CAS  PubMed  Google Scholar 

  18. Wilkinson CP (1981) Visual results following scleral buckling for retinal detachments sparing the macula. Retina 1(2):113–116

    Article  CAS  PubMed  Google Scholar 

  19. Burton TC (1982) Recovery of visual acuity after retinal detachment involving the macula. Trans Am Ophthalmol Soc 80:475–497

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Joe SG, Kim YJ, Chae JB, Yang SJ, Lee JY, Kim JG, Yoon YH (2013) Structural recovery of the detached macula after retinal detachment repair as assessed by optical coherence tomography. Korean J Ophthalmol 27(3):178–185. https://doi.org/10.3341/kjo.2013.27.3.178

    Article  PubMed  PubMed Central  Google Scholar 

  21. Hood DC, Zhang X, Ramachandran R, Talamini CL, Raza A, Greenberg JP, Sherman J, Tsang SH, Birch DG (2011) The inner segment/outer segment border seen on optical coherence tomography is less intense in patients with diminished cone function. Invest Ophthalmol Vis Sci 52(13):9703–9709. https://doi.org/10.1167/iovs.11-8650

    Article  PubMed  PubMed Central  Google Scholar 

  22. Witmer MT, Cho M, Favarone G, Chan RV, D'Amico DJ, Kiss S (2012) Ultra-wide-field autofluorescence imaging in non-traumatic rhegmatogenous retinal detachment. Eye (Lond) 26(9):1209–1216. https://doi.org/10.1038/eye.2012.122

    Article  CAS  Google Scholar 

  23. Holz FG, Bellman C, Staudt S, Schutt F, Volcker HE (2001) Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci 42(5):1051–1056

    CAS  PubMed  Google Scholar 

  24. Schmitz-Valckenberg S, Bindewald-Wittich A, Dolar-Szczasny J, Dreyhaupt J, Wolf S, Scholl HP, Holz FG, Fundus Autofluorescence in Age-Related Macular Degeneration Study G (2006) Correlation between the area of increased autofluorescence surrounding geographic atrophy and disease progression in patients with AMD. Invest Ophthalmol Vis Sci 47(6):2648–2654. https://doi.org/10.1167/iovs.05-0892

    Article  PubMed  Google Scholar 

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Funding

This study was funded by grants from Alice Rasmussen Memorial Fund, the Foundation of A. P. Møller and Chastine Mc-Kinney Møller, the Research Grant at the University of Southern Denmark, Director Jakob Madsen and Wife Olga Madsen Foundation, King Christian the X Foundation, Henry and Astrid Møller’s Foundation, A.J. Andersen and Wife Foundation, Einar Willumsen’s Memorial Fund, Department of Clinical Research Foundation at Odense University Hospital, the Region of Southern Denmark, and the Institute of Clinical Research at the University of Southern Denmark.

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Authors and Affiliations

  1. Department of Ophthalmology, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense, Denmark

    Christina Doefler Poulsen, M. P. Petersen & J. Grauslund

  2. Department of Clinical Research, University of Southern Denmark, Odense, Denmark

    Christina Doefler Poulsen, A. Green & T. Peto

  3. OPEN, Odense Patient data Explorative Network, Odense University Hospital/Department of Clinical Research, University of Southern Denmark, Odense, Denmark

    Christina Doefler Poulsen & A. Green

  4. Centre for Public Health, Queen’s University Belfast, Belfast, UK

    T. Peto

Authors
  1. Christina Doefler Poulsen
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  2. M. P. Petersen
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  4. T. Peto
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  5. J. Grauslund
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Contributions

CDP, JG, TP, and AG contributed to the concept and design of the study. CDP contributed to the acquisition of data. MPP contributed to the grading of SD-OCT images.

Data analyses were performed by CDP, who also wrote the initial draft of the paper. AG, TP, and JG revised the paper critically for intellectual content. All the authors approved the final version of the paper.

Corresponding author

Correspondence to Christina Doefler Poulsen.

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Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

This study was approved by the Danish Data Protection Agency and the Research Ethics Committee of the Region of Southern Denmark. All parts of the study were conducted in accordance with the Helsinki declaration II and in accordance with good clinical practice.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Poulsen, C.D., Petersen, M.P., Green, A. et al. Fundus autofluorescence and spectral domain optical coherence tomography as predictors for long-term functional outcome in rhegmatogenous retinal detachment. Graefes Arch Clin Exp Ophthalmol 257, 715–723 (2019). https://doi.org/10.1007/s00417-018-04222-w

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  • DOI: https://doi.org/10.1007/s00417-018-04222-w

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