Association of Bruch’s membrane opening and optic disc morphology to axial length and visual field defects in eyes with primary open-angle glaucoma

Abstract

Purpose

To examine the morphology of Bruch’s membrane opening (BMO), optic disc, and peripapillary atrophy (PPA) by scanning laser ophthalmoscopy (SLO) and spectral-domain optical coherence tomography (SD-OCT), and to determine their association with the axial length and visual field defects.

Methods

This was a cross-sectional study of 94 eyes of 56 subjects; 77 eyes were diagnosed with primary open-angle glaucoma and 17 eyes as normal. The margins of the optic disc were determined in the SLO images, and that of the BMO in the SD-OCT images. The ovality and area of the BMO and the optic disc were measured. The beta and gamma-PPA areas were also measured. The association of each parameter with the axial length and the mean deviation (MD) of the visual field tests was determined by generalized estimating equations (GEEs).

Results

The optic disc ovality was associated with the axial length and the MD (β = −0.47, P = 7.6 × 10−4 and β = 0.12, P = 0.040). The BMO ovality was not significantly associated with the axial length and the MD. The BMO area was associated with the axial length (β = 0.30, P = 0.029). A larger BMO area was associated with a thinner BMO-based neuroretinal rim width (BMO-MRW) after adjustments for the MD (β = −0.30, P = 2.1 × 10−4). The beta- and gamma-PPA areas were associated with the axial length (β = 0.50, P = 7.4 × 10−5 and β = 0.62, P = 4.2 × 10−6).

Conclusions

The optic disc ovality was associated with both the axial length and MD, whereas BMO ovality was not. Attention should be paid to the influence of the axial length-related enlargement of the BMO.

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Acknowledgements

This study was partly supported by the Innovative Techno-Hub for Integrated Medical Bio-Imaging of the Project for Developing Innovation Systems, from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.

Funding

This study was partly supported by the Innovative Techno-Hub for Integrated Medical Bio-Imaging of the Project for Developing Innovation Systems, from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. This study was also partly supported by grants from Grant-in-Aid for Scientific Research (25462713) from the Japan Society for the Promotion of Science (JSPS). These sponsors had no role in the design or conduct of this research.

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Correspondence to Hideo Nakanishi.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or non-financial interest in the subject matter or materials discussed in this manuscript.

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All procedures performed in this retrospective, observation study involving human participants were in accordance with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The procedures were approved by the Institutional Review Board and Ethics Committee of Kyoto University Graduate School of Medicine. For this type of study, formal consent is not required in our institution.

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Nakanishi, H., Suda, K., Yoshikawa, M. et al. Association of Bruch’s membrane opening and optic disc morphology to axial length and visual field defects in eyes with primary open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol 256, 599–610 (2018). https://doi.org/10.1007/s00417-017-3874-8

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Keywords

  • Glaucoma
  • Bruch’s membrane opening
  • Optic disc
  • Axial length
  • Tilted disc
  • Optic nerve head
  • Bruch’s membrane opening minimum rim width