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Quantitative changes in flow density in patients with adult-onset foveomacular vitelliform dystrophy: an OCT angiography study

Graefe's Archive for Clinical and Experimental Ophthalmology volume 256, pages 23–28 (2018)Cite this article

Abstract

Purpose

To quantitatively compare the flow density, the retinal thickness, and the area of the foveal avascular zone (FAZ) between patients with adult-onset foveomacular vitelliform dystrophy (AOFVD) and a healthy controls.

Methods

Thirteen eyes (eight patients) with AOFVD and 13 matched eyes (13 patients) without any ocular pathology were included in this study. A 6 × 6 mm optical coherence tomography angiography (OCTA) scan was performed for every included eye. The flow density (superficial retinal vascular layer, deep retinal vascular layer and choriocapillary layer), retinal thickness and FAZ (superficial retinal vascular layer and deep retinal vascular layer) were subsequently analyzed.

Results

The mean flow density was decreased in the AOFVD patients in all measured vascular layers. The difference from the control group was statistically significant in the parafoveal sector of the deep retinal vascular layer (P = 0.02), and a clear trend was found in the superficial retinal vascular layer (P = 0.05). Both groups had comparable FAZs in the superficial and deep retinal vascular layers. The retinal thickness values were higher in the fovea (P = 0.840) and lower in the parafoveal sectors (P = 0.125). The difference was significant in the superior parafoveal sector (P = 0.034).

Conclusions

Flow densities as measured by OCTA are decreased in the superficial retinal vascular layer and the deep retinal vascular layer in patients with AOFVD. These findings could be helpful for diagnosing and understanding the pathogenesis of this disease.

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Affiliations

  1. Department of Ophthalmology, University of Muenster Medical Center, Domagkstraße 15, 48149, Muenster, Germany

    Maximilian Treder, Jost Lennart Lauermann, Maged Alnawaiseh, Peter Heiduschka & Nicole Eter

Authors
  1. Maximilian Treder
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  2. Jost Lennart Lauermann
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  3. Maged Alnawaiseh
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  4. Peter Heiduschka
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  5. Nicole Eter
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Corresponding author

Correspondence to Maximilian Treder.

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Financial support

No funding was received for this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Financial disclosure

M. Treder: Allergan, Novartis; J.L. Lauermann: Novartis; M. Alnawaiseh: Novartis; P. Heiduschka: Bayer, Novartis; N. Eter: Allergan, Alimera, Bausch and Lomb, Bayer, Heidelberg Engineering, Novartis, Roche.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Cite this article

Treder, M., Lauermann, J.L., Alnawaiseh, M. et al. Quantitative changes in flow density in patients with adult-onset foveomacular vitelliform dystrophy: an OCT angiography study. Graefes Arch Clin Exp Ophthalmol 256, 23–28 (2018). https://doi.org/10.1007/s00417-017-3815-6

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  • DOI: https://doi.org/10.1007/s00417-017-3815-6

Keywords

  • Optical coherence tomography angiography
  • Adult-onset foveomacular vitelliform dystrophy
  • Flow density
  • Foveal avascular zone