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Characteristics of retinal vessels in surgically closed macular hole: an optical coherence tomography angiography study

  • Retinal Disorders
  • Published:
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Abstract

Purpose

The purpose of our study was to investigate characteristics of retinal vessels in eyes with surgically closed macular holes (MH).

Methods

We included patients who underwent surgery for idiopathic MH and a follow-up examination using optical coherence tomography angiography (OCTA). The area of the foveal avascular zone (FAZ) and retinal vascular densities of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were calculated on the postoperative OCTA images and compared with those of age-matched normal controls.

Results

Twenty-eight patients with MH and 28 controls were included. Mean postoperative FAZ areas of SCP and DCP (0.317 ± 0.129 mm2 and 0.500 ± 0.174 mm2) were smaller than those of normal controls (0.406 ± 0.131 mm2 and 0.687 ± 0.147 mm2) (P = 0.013 and P < 0.001, respectively). Retinal vascular densities of SCP and DCP in the MH group (32.23 ± 1.45% and 31.85 ± 1.28%) were lower than those of the control group (33.26 ± 1.71% and 33.18 ± 1.89%) (P = 0.019 and P = 0.003, respectively). The retinal vascular densities of SCP and DCP were associated with postoperative mean ganglion cell–inner plexiform layer (GC-IPL) thickness (P = 0.033 and P = 0.035, respectively). The vascular densities were horizontally asymmetric and related to asymmetric distribution of GC-IPL thickness in the MH group.

Conclusions

Surgically closed MH eyes had remodeled retinal vascular patterns, which were related to morphologic changes in the inner retinal layer. The healing process after MH surgery may be involved in asymmetric change in anatomy and hemodynamics of the inner retina.

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Authors and Affiliations

  1. Department of Ophthalmology, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Sungbuk-gu, Seoul, 136-705, South Korea

    Cheolmin Yun, Jaemoon Ahn, Mingue Kim, Seong-Woo Kim & Jaeryung Oh

  2. Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, South Korea

    Jee Taek Kim

  3. Department of Biostatistics, Korea University College of Medicine, Seoul, South Korea

    Soon-Young Hwang

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  1. Cheolmin Yun
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  2. Jaemoon Ahn
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  3. Mingue Kim
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Correspondence to Jaeryung Oh.

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Funding

This manuscript is based upon work supported by the Ministry of Trade, Industry & Energy (MOTIE, Korea) under the Industrial Technology Innovation (10063364).

Conflict of interest

J. O. is a consultant of Topcon Corporation. Other authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

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Yun, C., Ahn, J., Kim, M. et al. Characteristics of retinal vessels in surgically closed macular hole: an optical coherence tomography angiography study. Graefes Arch Clin Exp Ophthalmol 255, 1923–1934 (2017). https://doi.org/10.1007/s00417-017-3742-6

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