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Intraocular silicone implant to treat chronic ocular hypotony: an in vivo trial

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Abstract

Purpose

The management of chronic ocular hypotony and complicated proliferative vitreoretinopathy-related retinal detachment represents a challenge. Being non-absorbable and non-biodegradable, a silicone oil implant is expected to restore the volume and the intraocular pressure of the globe, as well as to approximate the detached retina. Further advantages could be a long-term tamponade potential, absence of toxicity, and prevention of silicone oil emulsification or anterior chamber oil-prolapse. The aim of this study was to assess the histological tolerance of the silicone oil implant in a pig model.

Methods

A seamless silicone balloon implant with optional surface modifications was developed. Mini pigs were used as experimental animals, and three variants of silicone implants with different surfaces were tested: uncoated, NCO-sP(EO-stat-PO) coated, and heparin-NCO-sP(EO-stat-PO) coated silicone implants. An extracapsular lens extraction was achieved via a standard phacoemulsification followed by a standard three-port vitrectomy. The implant was then placed in the posterior segment and filled with 5000 centistoke silicone oil. One month later, the pigs were euthanized, the eyes were enucleated, and histological specimens were prepared for microscopy.

Results

The analysis of the histology revealed that adverse histological changes in conjunctiva, cornea, iris, and ciliary body could be excluded in all eyes operated on regardless of which variant of implant had been employed. The retina as the implant-contacting ocular tissue showed overall good tolerance, although some inflammatory reaction and fibrous proliferation was evident in some cases.

Conclusions

The silicone oil implant is a promising candidate and has the potential to fulfill clinical requirements to act as a long-term intraocular tamponade agent. The heparin-NCO-sP(EO-stat-PO) coating approach could lead to a novel bioactive surface for intraocular devices with excellent properties to hinder cell adhesion and protein adsorption, although further studies will be necessary to evaluate long-term biocompatibility and long-term resistance to biological attacks.

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Authors and Affiliations

  1. Department of Ophthalmology, RWTH Aachen University, Aachen, Germany

    Wesal Bayoudh, Dörthe Carstesen, Peter Walter & Andreas W. A. Weinberger

  2. Department of Ophthalmology, Klinikum Dortmund gGmbH, Beurhausstraße 40, 44137, Dortmund, Germany

    Wesal Bayoudh

  3. Augenklinik Starnberg, Starnberg, Germany

    Andreas W. A. Weinberger

  4. Department of Ophthalmology, University Hospitals of Geneva, Geneva, Switzerland

    Andreas W. A. Weinberger

Authors
  1. Wesal Bayoudh
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  2. Dörthe Carstesen
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  3. Peter Walter
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  4. Andreas W. A. Weinberger
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Corresponding author

Correspondence to Wesal Bayoudh.

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Funding

The Interdisciplinary Centre for Clinical Research “BIOMAT” and the START program, both within the faculty of Medicine at the RWTH Aachen University, provided financial support in the form of grant funding. The sponsor had no role in the design or conduct of this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria, educational grants, participation in speakers’ bureaus, membership, employment, consultancies, stock ownership, other equity interest, expert testimony, or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.

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Bayoudh, W., Carstesen, D., Walter, P. et al. Intraocular silicone implant to treat chronic ocular hypotony: an in vivo trial. Graefes Arch Clin Exp Ophthalmol 255, 1947–1955 (2017). https://doi.org/10.1007/s00417-017-3714-x

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  • DOI: https://doi.org/10.1007/s00417-017-3714-x

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