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Optical coherence tomography angiography in pre-perimetric open-angle glaucoma

  • Glaucoma
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the diagnostic efficacy of optical coherence tomography (OCT) angiography, in patients with pre-perimetric open-angle glaucoma.

Methods

Thirty-eight consecutive eyes of 26 patients with pre-perimetric open-angle glaucoma and 48 normal eyes of 32 controls were included in this prospective study. We evaluated OCT angiography, spectral-domain OCT and visual fields parameters. Differences between controls and patients and between OCT angiography parameters and traditional glaucoma measurements were evaluated. Receiver operating characteristic curves for OCT angiography parameters were assessed.

Results

The flow index (p = 0.021) and vessel density (p = 0.001) were significantly lower in pre-perimetric glaucoma eyes versus normal eyes. Ganglion cell complex parameters were significantly correlated to OCT angiography parameters (p < 0.05). Neither retinal nerve fiber layer (RNFL) nor visual field parameters correlated with OCT angiography parameters.

Conclusions

OCT angiography can be considered a reliable, easy-to-perform method with which to evaluate microvascular changes of optic nerve head for the early diagnosis and follow-up of glaucoma.

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Authors and Affiliations

  1. Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Via S. Pansini 5, 80133, Naples, Italy

    Gilda Cennamo, Daniela Montorio, Nunzio Velotti, Federica Sparnelli & Giovanni Cennamo

  2. Eye Clinic, University of Catania, Catania, Italy

    Michele Reibaldi

Authors
  1. Gilda Cennamo
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  2. Daniela Montorio
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  3. Nunzio Velotti
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  4. Federica Sparnelli
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  5. Michele Reibaldi
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  6. Giovanni Cennamo
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Corresponding author

Correspondence to Gilda Cennamo.

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Funding

No funding was received for this research.

Conflict of interests

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationship, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Cite this article

Cennamo, G., Montorio, D., Velotti, N. et al. Optical coherence tomography angiography in pre-perimetric open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol 255, 1787–1793 (2017). https://doi.org/10.1007/s00417-017-3709-7

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  • DOI: https://doi.org/10.1007/s00417-017-3709-7

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