Switching therapy from bevacizumab to aflibercept for the management of persistent diabetic macular edema

  • Dan Călugăru
  • Mihai Călugăru
Letter to the Editor

Dear Editor:

We would to address several challenges that have arisen from the study by Bahrami et al. [1] which can be specifically summarized below.

Several relevant data are missing from the study (Table 1).
Table 1

Missing data from the article by Bahrami et al. [1]


DME patterns (diffuse/subretinal fluid/cystic changes within neurosensory retina/mixed type) at week 24

Diabetic retinopathy types (proliferative/non-proliferative) at enrollment and at the end of the study

Qualitative status of the two outer retinal layers (e.g., the interdigitation zone and the retinal pigment epithelial band) at baseline and the magnitude of the changes (disruption/absence) in all the four outer retinal layers at week 24

Prevalence of epiretinal membrane at baseline and their changes during the study as potential predictive factors on anatomic and visual outcomes after treatment with aflibercept

Fluorecein angiographic findings (focal leakage from microaneurisms or dilated capillaries,...


Vascular Endothelial Growth Factor Bevacizumab Ranibizumab Diabetic Macular Edema Aflibercept 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors have full control of the primary data, and they agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review their data if requested.

Compliance with ethical standards

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.


All authors have completed and submitted the ICMJE form for disclosure of potential conflicts of interest. No financial disclosures. Both authors (D.C and M.C) were involved in design and conduct of the study; collection, management, analysis and interpretation of the data; and preparation, review or approval of the manuscript.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of OphthalmologyUniversity of Medicine Cluj-Napoca/RomaniaCluj-NapocaRomania

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