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Intravitreal dexamethasone implant for recalcitrant cystoid macular edema secondary to retinitis pigmentosa: a pilot study

  • Retinal Disorders
  • Published:
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Abstract

Background

To determine the utility of the intravitreal dexamethasone implant as therapy for cystoid macular edema (CME) secondary to retinitis pigmentosa (RP) recalcitrant to carbonic anhydrase inhibitor therapy over 2 years as a pilot study.

Methods

This was a prospective case series. Patients who showed either an incomplete or no response to topical dorzolamide for at least 1 month and oral acetazolamide therapy for at least 15 days were recruited for the study with informed consent. A complete anterior and posterior segment examination was performed including fundus fluorescein angiography (FFA), optical coherence tomography scan (OCT) and electroretinogram to confirm the diagnosis. The dexamethasone implant was injected using a standardized technique. Follow ups were scheduled on days 1, 7, and 30 and then monthly thereafter for 2 years. The primary outcome measure was the change in corrected distance visual acuity (CDVA) and central subfield thickness (CST) at months 1, 6, 12, 18, and 24. The secondary outcome measure was complications, if any. Appropriate statistical analysis was done.

Results

Five patients (two males; six eyes; median age 49 years) were recruited for the study. All patients required at least two injections over 2 years. All patients demonstrated significant improvement in CDVA (p = 0.004) as well as CST measurements (p = 0.0038) over 2 years. No complications were noted.

Conclusion

The intravitreal dexamethasone implant provides significant improvement in CDVA and CST measurements in patients with recalcitrant CME secondary to RP.

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Authors and Affiliations

  1. Eye Hospital and Retina Centre, Mahajan Lane, Raopura, Baroda, 390002, India

    Aditya Sudhalkar & Nishikant Borse

  2. Department of Ophthalmology, Croix-Rousse Teaching Hospital, Hospices Civils de Lyon, UMR-CNRS 5510 Matéis, University of Medicine Lyon 1, Lyon, France

    Laurent Kodjikian

Authors
  1. Aditya Sudhalkar
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  2. Laurent Kodjikian
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  3. Nishikant Borse
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Corresponding author

Correspondence to Aditya Sudhalkar.

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Funding

No funding was received for this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Financial support

None

Aditya Sudhalkar and Nishikant Borse have no financial interests to declare

Laurent Kodjikian is a consultant for Alcon, Allergan, Alimera, Bayer, Novartis, and Théa.

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Sudhalkar, A., Kodjikian, L. & Borse, N. Intravitreal dexamethasone implant for recalcitrant cystoid macular edema secondary to retinitis pigmentosa: a pilot study. Graefes Arch Clin Exp Ophthalmol 255, 1369–1374 (2017). https://doi.org/10.1007/s00417-017-3660-7

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  • DOI: https://doi.org/10.1007/s00417-017-3660-7

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