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Feasibility of swept-source OCT for active birdshot chorioretinopathy

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To assess the feasibility of swept-source optical coherence tomography (SS-OCT) for clinical follow-up of patients with birdshot chorioretinopathy (BC).

Methods

Prospective longitudinal, observational, 12-month case–control study in a tertiary care center. The study population included 12 patients (24 eyes) diagnosed with BC and 21 age- and sex-matched healthy controls (42 eyes). The macular areas in both affected and healthy eyes were prospectively analyzed with SS-OCT at 1050 nm, using 2D 12.0-mm radial and horizontal scans and the 3D raster scan protocol (12.0 × 9.0 mm). Anatomical and structural abnormalities, as well as retinal and choroidal thickness (measured automatically), were evaluated and compared with visual field (VF) testing and indocyanine green angiography (ICGA).

Results

The most common qualitative abnormalities in the retina were thinning/loss of architecture and outer retinal hyperreflective foci, and in the choroid they were focal depigmentation, thinning/absence of Sattler’s layer, generalized thinning, and hyperreflective foci. The most significant changes in the retina from baseline to the 12-month follow-up were decreases in intraretinal cysts, subretinal fluid, and hyaloid thickening. In the choroid, focal depigmentation decreased significantly, while vascular pattern loss increased. Compared to the healthy volunteers, patients with BC had thinner choroids and retinas at both baseline and study end. Retinal thickness decreased significantly in BC patients over the 12-month study period, but choroidal thickness remained unchanged. Findings from ICGA, VF, and SS-OCT were perfectly correlated in most (≈ 60%) patients.

Conclusions

SS-OCT is a non-invasive, rapid method of assessing choroidal and retinal changes in patients with birdshot disease. This technique provides a simple method of monitoring the course of the disease that can be used to complement conventional tests.

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References

  1. Levinson RD, Brezin A, Rothova A et al (2006) Research criteria for the diagnosis of birdshot chorioretinopathy: results of an international consensus conference. Am J Ophthalmol 141:185–187

    Article  PubMed  Google Scholar 

  2. The Standardization of Uveitis Nomenclature (SUN) Working Group (2005) Standardization of uveitis Nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol 140:509–516

    Article  Google Scholar 

  3. Nussenblatt RB, Palestine AG, Chan C-C, Roberge F (1985) Standardization of vitreal inflammatory activity in intermediate and posterior uveitis. Ophthalmology 92:467–471

    Article  CAS  PubMed  Google Scholar 

  4. Baarsma GS, Priem HA, Kijlstra A (1990) Association of birdshot retinochoroidopathy and HLA-A29 antigen. Curr Eye Res 9:63–68

    Article  PubMed  Google Scholar 

  5. Nussenblatt RB, Mittal KK, Ryan S et al (1982) Birdshot retinochoroidopathy associated with HLA-A29 antigen and immune responsiveness to retinal S-antigen. Am J Ophthalmol 94:147–158

    Article  CAS  PubMed  Google Scholar 

  6. Fercher AF, Hitzenberger CK, Drexler W et al (1993) In vivo optical coherence tomography. Am J Ophthalmol 116:113–114

    Article  CAS  PubMed  Google Scholar 

  7. Branchini L, Regatieri CV, Flores-Moreno I et al (2012) Reproducibility of choroidal thickness measurements across three spectral domain optical coherence tomography systems. Ophthalmology 119:119–123

    Article  PubMed  Google Scholar 

  8. Barteselli G, Chhablani J, El-Emam S et al (2012) Choroidal volume variations with age, axial length, and sex in healthy subjects: a three-dimensional analysis. Ophthalmology 119:2572–2578

    Article  PubMed  PubMed Central  Google Scholar 

  9. Keane PA, Ruiz-Garcia H, Sadda SR (2011) Clinical applications of long-wavelength (1,000-nm) optical coherence tomography. Ophthalmic Surg Lasers Imaging 42:S67–S74

    Article  PubMed  Google Scholar 

  10. Margolis R, Spaide RF (2009) A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol 147:811–815

    Article  PubMed  Google Scholar 

  11. Spaide RF, Koizumi H, Pozonni MC (2008) Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 146:496–500

    Article  PubMed  Google Scholar 

  12. Hirata M, Tsujikawa A, Matsumoto A et al (2011) Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography. Investig Opthalmol Vis Sci 52:4971. doi:10.1167/iovs.11-7729

    Article  Google Scholar 

  13. Giani A, Cigada M, Choudhry N et al (2010) Reproducibility of retinal thickness measurements on normal and pathologic eyes by different optical coherence tomography instruments. Am J Ophthalmol 150:815–824.e1

    Article  Google Scholar 

  14. Tian J, Marziliano P, Baskaran M et al (2013) Automatic segmentation of the choroid in enhanced depth imaging optical coherence tomography images. Biomed Opt Express 4:397

    Article  PubMed  PubMed Central  Google Scholar 

  15. Rahman W, Chen FK, Yeoh J et al (2011) Repeatability of manual subfoveal choroidal thickness measurements in healthy subjects using the technique of enhanced depth imaging optical coherence tomography. Investig Opthalmol Vis Sci 52:2267

    Article  Google Scholar 

  16. Keane PA, Allie M, Turner SJ et al (2013) Characterization of birdshot chorioretinopathy using extramacular enhanced depth optical coherence tomography. JAMA Ophthalmol 131:341

    Article  PubMed  Google Scholar 

  17. Ruiz-Medrano J, Flores-Moreno I, Peña-García P et al (2014) Macular choroidal thickness profile in a healthy population measured by swept-source optical coherence tomography. Investig Opthalmol Vis Sci 55:3532

    Article  Google Scholar 

  18. Choma M, Sarunic M, Yang C, Izatt J (2003) Sensitivity advantage of swept source and Fourier domain optical coherence tomography. Opt Express 11:2183

    Article  PubMed  Google Scholar 

  19. Fujiwara T, Imamura Y, Margolis R et al (2009) Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am J Ophthalmol 148:445–450

    Article  PubMed  Google Scholar 

  20. Kahn KN, McKibbin M, Kahn RS (2011) Variability in subfoveal choroidal thickness measurements. Investig Opthalmol Vis Sci 52:7221

    Article  Google Scholar 

  21. Holladay JT (2004) Visual acuity measurements. J Cataract Refract Surg 30:287–290

    Article  PubMed  Google Scholar 

  22. Invernizzi A, Mapelli C, Viola F et al (2015) Choroidal granulomas visualized by enhanced depth imaging optical coherence tomography. Retina 35:525–531

    Article  PubMed  Google Scholar 

  23. Papadia M, Jeannin B, Herbort CP (2012) OCT findings in birdshot chorioretinitis: a glimpse into retinal disease evolution. Ophthalmic Surg Lasers Imaging 43:S25–S31

    Article  PubMed  Google Scholar 

  24. Oh KT, Christmas NJ, Folk JC (2002) Birdshot retinochoroiditis: long term follow-up of a chronically progressive disease. Am J Ophthalmol 133:622–629

    Article  PubMed  Google Scholar 

  25. Sobrin L, Lam BL, Liu M et al (2005) Electroretinographic monitoring in birdshot chorioretinopathy. Am J Ophthalmol 140:52.e1–52.e18

    Article  Google Scholar 

  26. Kiss S, Ahmed M, Letko E, Foster C (2005) Long-term follow-up of patients with birdshot retinochoroidopathy treated with corticosteroid-sparing systemic immunomodulatory therapy. Ophthalmology 112:1066–1071.e2

    Article  Google Scholar 

  27. de Courten C, Herbort CP (1998) Potential role of computerized visual field testing for the appraisal and follow-up of birdshot chorioretinopathy. Arch Ophthalmol 116:1389–1391

    PubMed  Google Scholar 

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Acknowledgements

We would like to thank Bradley Londres for his assistance in editing and improving the English language in this report.

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Authors and Affiliations

  1. Ophthalmology Department, University Hospital of Bellvitge, Hospitalet de Llobregat, Barcelona, Spain

    Olga Garcia-Garcia, Sara Jordan-Cumplido, Olaia Subira-Gonzalez, Pere Garcia-Bru, Luis Arias & Josep M. Caminal-Mitjana

  2. Ophthalmology Department, Hospital Universitari Bellvitge, c/ Feixa Llarga s/n, 08907 Hospitalet Llobregat, Barcelona, Spain

    Olga Garcia-Garcia

Authors
  1. Olga Garcia-Garcia
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  2. Sara Jordan-Cumplido
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  3. Olaia Subira-Gonzalez
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  4. Pere Garcia-Bru
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  5. Luis Arias
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  6. Josep M. Caminal-Mitjana
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Corresponding author

Correspondence to Olga Garcia-Garcia.

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Financial support

No funding was received for this study. None of the authors has any financial interests to declare.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

The study was approved by the local research ethics committee (CEIC of the University Hospital of Bellvitge, reference no. PR204/14).

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Each co-author meets the requirements for authorship.

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Garcia-Garcia, O., Jordan-Cumplido, S., Subira-Gonzalez, O. et al. Feasibility of swept-source OCT for active birdshot chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 255, 1493–1502 (2017). https://doi.org/10.1007/s00417-017-3655-4

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  • DOI: https://doi.org/10.1007/s00417-017-3655-4

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