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The effect of center point shift on the measurement of macular thickness: a spectral domain-optical coherence tomography study

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the effect of spectral domain-optical coherence tomography (SD-OCT) measurement center shift on the measurement of macular thickness.

Methods

This was a prospective observational case series. A total of 60 normal eyes of 60 subjects included in the study. SD-OCT macular scanning (macular cube 512 × 128 scan) was performed twice by an experienced examiner. The average retinal thicknesses of the nine macular sectors as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) were recorded. Each coefficient of repeatability was calculated for the macular thickness measurements of the ETDRS subfields. Thereafter, the measurement center was manually decentered to a seven scan point, each from the central fovea in steps of 58.7 μm horizontally and 47.2 μm vertically. At each shift point, the change in the macular thickness was compared.

Results

When the displacement distance between the measurement center point and the foveal center was within 117.4 μm horizontally and 141.6 μm vertically, the macular thickness measurements did not show any significant differences. However, if the offset of the EDTRS grid center from the anatomic fovea exceeded, we noted that the thickness at the fovea increased and the opposite-direction region at the inner circle was significantly thinner than the displaced point.

Conclusions

The effect of measurement center shift needs to be considered when analyzing the macular thickness measurements in various ophthalmologic diseases.

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Authors and Affiliations

  1. Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea

    Kyoung Nam Kim, Il Hwan Shin, Jae Yun Sung, Hyung Bin Lim, Young Joon Jo & Jung Yeul Kim

  2. Department of Computer Engineering, San Jose State University, San Jose, CA, USA

    Baek Soo Kwak

  3. Research Institute for Medical Science, Chungnam National University College of Medicine, Daejeon, Republic of Korea

    Young Joon Jo & Jung Yeul Kim

  4. Department of Ophthalmology, Chungnam National University Hospital, #640 Daesa-dong, Jung-gu, Daejeon, 301-721, South Korea

    Jung Yeul Kim

Authors
  1. Kyoung Nam Kim
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  2. Il Hwan Shin
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  3. Jae Yun Sung
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  5. Hyung Bin Lim
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Corresponding author

Correspondence to Jung Yeul Kim.

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Funding

This study was financially supported by the research fund of Chungnam National University in 2016.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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For retrospective studies, formal consent is not required.

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Kim, K.N., Shin, I.H., Sung, J.Y. et al. The effect of center point shift on the measurement of macular thickness: a spectral domain-optical coherence tomography study. Graefes Arch Clin Exp Ophthalmol 255, 1107–1113 (2017). https://doi.org/10.1007/s00417-017-3615-z

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  • DOI: https://doi.org/10.1007/s00417-017-3615-z

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