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Peripapillary retinal vessel density in eyes with acute primary angle closure: an optical coherence tomography angiography study

  • Glaucoma
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

The purpose was to investigate peripapillary retinal vessel density in resolved acute primary angle closure (APAC) eyes.

Methods

This was a prospective, cross-sectional observational study. Thirty-four eyes of 34 patients with unilateral APAC were included, together with the fellow eyes with primary angle closure suspect (PACS) as controls. Peripapillary retinal vessel density was measured using optical coherence tomography (OCT) angiography. Peripapillary retinal vessel density was compared in both eyes and the potential relationship with visual field (VF) test results was evaluated.

Results

After an acute attack, the peripapillary retinal vessel density was lower in the APAC than in the PACS eyes (79.3 ± 8.2 versus 85.6 ± 4.9, respectively; P = 0.001). The VF mean deviation (MD) (-7.7 ± 6.7 versus -3.3 ± 1.8 dB, P = 0.002), and the pattern standard deviation (PSD) (4.6 ± 3.3 versus 2.4 ± 0.9 dB, P = 0.001) were worse for the APAC than the PACS eyes, but both had similar thicknesses of the retinal nerve fiber layer (RNFL) (111.8 ± 9.6 versus 114.1 ± 29.1 μm, P = 0.880) and ganglion cell complex (GCC) (94.7 ± 7.5 versus 91.8 ± 9.3 μm, P = 0.328). The peripapillary retinal vessel density was significantly correlated with the VF MD (vessel density: r = 0.455, P = 0.008) and PSD (vessel density: r = -0.592, P < 0.001) in the APAC eyes.

Conclusions

Even when IOP was normalized after the acute attack, the APAC eyes had a lower peripapillary retinal vessel density, which was correlated with the VF values. OCT angiography is a reliable method for detecting vascular changes in glaucomatous eyes that show no thinning of the RNFL and GCC.

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Author notes

    Authors and Affiliations

    1. Department of Ophthalmology and Visual Science, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College of Fudan University, 83 Fenyang Road, Shanghai, 200031, China

      Xiaolei Wang, Chunhui Jiang, Xiangmei Kong, Xiaobo Yu & Xinghuai Sun

    2. Key Laboratory of Myopia, and Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, 200031, China

      Xiangmei Kong, Xiaobo Yu & Xinghuai Sun

    3. State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 200032, China

      Xinghuai Sun

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    1. Xiaolei Wang
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    2. Chunhui Jiang
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    3. Xiangmei Kong
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    4. Xiaobo Yu
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    Correspondence to Xinghuai Sun.

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    Funding statement

    Project supported by the State Key Program of National Natural Science Foundation of China (Grant No. 81430007, China), by the National Major Scientific Equipment program (Grant No. 2012YQ12008003, China), by the Special Scientific Research Project of Health Professions (Grant No. 201302015, China) and by the Shanghai Committee of Science and Technology (Grant No.13430710500 and 15DZ1942204 China).

    Conflict of interest

    All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

    Ethical approval

    All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

    Informed consent

    Informed consent was obtained from all individual participants included in the study.

    Additional information

    Xiaolei Wang and Chunhui Jiang contributed equally to this work.

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    Wang, X., Jiang, C., Kong, X. et al. Peripapillary retinal vessel density in eyes with acute primary angle closure: an optical coherence tomography angiography study. Graefes Arch Clin Exp Ophthalmol 255, 1013–1018 (2017). https://doi.org/10.1007/s00417-017-3593-1

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    • DOI: https://doi.org/10.1007/s00417-017-3593-1

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