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OCT angiography quantifying choriocapillary circulation in idiopathic macular hole before and after surgery

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To investigate the choriocapillary circulation in the macular area for eyes with unilateral idiopathic macular hole (IMH) before and after vitrectomy using optical coherence tomography angiography (OCTA).

Methods

A prospective study of 25 patients with unilateral IMH who underwent vitrectomy and 30 age- and sex-matched healthy controls were recruited. Choriocapillary circulation was measured by OCTA to obtain two measurements: flow area and parafovea vessel density.

Results

Flow area and parafovea vessel density of choriocapillaris in the macular area were significantly smaller and lower in IMH eyes than unaffected fellow eyes and healthy control eyes (p < 0.001), while no difference was found between unaffected fellow eyes and the healthy control eyes. One month after vitrectomy, the choriocapillary flow area and parafovea vessel density of IMH eyes significantly increased compared to the peroperative measurements (p < 0.001). Association analysis found that choriocapillary circulation measurements were negatively correlated with macular hole diameters in IMH eyes (p < 0.001), but was independent with best-corrected visual acuity (BCVA).

Conclusions

The macular choriocapillary flow area and parafovea vessel density in IMH eyes were lower than those of normal controls. In addition, the choriocapillary circulation was negatively correlated with macular hole diameter. Our findings suggested that choroidal circulation in the macular area might be affected by the intact structure of the fovea.

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Author information

Authors and Affiliations

  1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, 1 Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China

    Yufei Teng, Yi Wang, Qisheng You & Wu Liu

  2. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, 17 Hougouhutong Street, Dongcheng District, Beijing, 100005, China

    Yufei Teng & Qisheng You

  3. Department of Mathematics and Statistics, Hang Seng Management College, Hang Shin Link, Siu Lek Yuen, Shatin, N.T, Hong Kong, China

    Marco Yu

  4. Department of Ophthalmology, Kailuan General Hospital, Hebei United University, Tangshan, China

    Xinxin Liu

Authors
  1. Yufei Teng
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  2. Marco Yu
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  3. Yi Wang
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  4. Xinxin Liu
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  5. Qisheng You
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  6. Wu Liu
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Correspondence to Wu Liu.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Teng, Y., Yu, M., Wang, Y. et al. OCT angiography quantifying choriocapillary circulation in idiopathic macular hole before and after surgery. Graefes Arch Clin Exp Ophthalmol 255, 893–902 (2017). https://doi.org/10.1007/s00417-017-3586-0

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  • DOI: https://doi.org/10.1007/s00417-017-3586-0

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