Skip to main content

Advertisement

SpringerLink
Log in

Spectral-domain optical coherence tomography findings in idiopathic lamellar macular hole

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Background

To evaluate demographic, functional, and morphological parameters of idiopathic lamellar macular hole (ILMH).

Methods

Observational longitudinal retrospective study.

Optical coherence tomography examinations and corresponding clinical charts of a series of consecutive patients affected by ILMH, between January 2010 and March 2015, from the database of the Department of Ophthalmology of Trento Hospital, Italy, have been collected and examined.

Demographic and functional parameters were: age (year), gender (male/female), eye (right/left), lens status, best-corrected visual acuity (BCVA) in logarithm of the minimum angle of resolution (LogMAR).

Tomographic parameters were: LMH shape pattern (intraretinal splitting LMH, IR split LMH, and V-shaped LMH, V LMH), posterior vitreous detachment (PVD yes/ PVD no), ERM type (conventional ERM and atypical ERM), integrity of ellipsoid zone (EZ) and external limiting membrane (ELM), residual foveal thickness (RFT) micron (μ), maximal diameter of intraretinal splitting (MDIRS) (μ).

Results

One hundred and eighty-nine eyes of 175 patients were included. The mean age was 72.84 ± 9.6, range 41–96 years. BCVA mean was 0.24 ± 0.25, range 0 –1.3 LogMAR. One hundred and forty-one eyes (74.6 %) were affected by IR split LMH, 48 eyes (25.4 %) were affected by V LMH. Every cases of ILMH were associated with ERM: 117 (61.9 %) conventional ERM, 72 (38.1 %) atypical ERM. A significant prevalence of female gender, phakic condition, and PVD in conventional ERM ILMH subgroup (P = 0.000) was found. BCVA mean was better in the conventional ERM ILMH subgroup (P = 0.000). An association between the interruption of the outer retinal layers (EZ and ELM) and atypical ERM ILMH subgroup was highlighted (P = 0.000). The statistical analysis showed a correlation between BCVA and integrity of ELM (P = 0.000). RFT significantly decreased in atypical ERM ILMH subgroup at 24 months compared to time point 0 (P = 0.027). A progressive increase of MDIRS in both subgroups at 12 months and in atypical ERM ILMH subgroup at 24 months (P = 0.007) was highlighted.

Conclusions

This study demonstrated that ILMH was not a stable condition, showing morphological changes and an involvement of the outer retinal layers during the 2 years of follow-up.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Witkin AJ, Ko TH, Fujimoto JG et al (2006) Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study. Ophthalmology 113(3):388–397

    Article  PubMed  PubMed Central  Google Scholar 

  2. Haouchine B, Massin P, Tadayoni R et al (2004) Diagnosis of macular pseudoholes and lamellar macular holes by optical coherence tomography. Am J Ophthalmol 138(5):732–739

    Article  PubMed  Google Scholar 

  3. Parolini B, Schumann RG, Cereda MG et al (2011) Lamellar macular hole: a clinicopathologic correlation of surgically excised epiretinal membranes. Invest Ophthalmol Vis Sci 25 52(12):9074–9083

    Article  Google Scholar 

  4. Bottoni F, Peroglio Deiro A, Giani A et al (2013) The natural history of lamellar macular holes: a spectral-domain optical coherence tomography study. Graefes Arch Clin Exp Ophthalmol 251:467–475

    Article  PubMed  Google Scholar 

  5. Pang CE, Spaide RF, Freund KB (2014) Epiretinal proliferation seen in association with lamellar macular holes: a distinct clinical entity. Retina 34(8):1513–1523

    Article  PubMed  Google Scholar 

  6. Pang CE, Spaide RF, Freund KB (2015) Comparing functional and morphological characteristics of lamellar macular hole with and without lamellar macular hole associated epiretinal proliferation. Retina 35(4):720–726

    Article  PubMed  Google Scholar 

  7. Govetto A, Dacquay Y, Farajzadeh M et al (2016) Lamellar macular hole: two distinct clinical entities? Am J Ophthalmol 164:99–109

    Article  PubMed  Google Scholar 

  8. Schumann RG, Compera D, Schaumberger MM et al (2015) Epiretinal membrane characteristics correlate with photoreceptor layer defects in lamellar macular holes and macular pseudoholes. Retina 35(4):727–735

    Article  PubMed  Google Scholar 

  9. Compera D, Entchev E, Haritoglou C et al (2015) Lamellar hole-associated epiretinal proliferation in comparison to epiretinal membranes of macular pseudoholes. Am J Ophthalmol 160(2):373–384

    Article  PubMed  Google Scholar 

  10. Allen AW Jr, Gass JD (1976) Contraction of a perifoveal epiretinal membrane simulating a macular hole. Am J Ophthalmol 82:684–691

    Article  PubMed  Google Scholar 

  11. Lujan BJ, Roorda A, Knighton RW (2011) Revealing Henle’s fiber layer using spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci 18 52(3):1486–1492

    Article  Google Scholar 

  12. Otani T, Yamaguchi Y, Kishi S (2011) Improved visualization of Henle fiber layer by changing the measurement beam angle on optical coherence tomography. Retina 31(3):497–501

    Article  PubMed  Google Scholar 

  13. Staurenghi G, Sadda S, Chakravarthy U (2014) Proposed lexicon for anatomic landmarks in normal posterior segment spectral-domain optical coherence tomography: the IN•OCT consensus. Ophthalmology 121(8):1572–1578

    Article  PubMed  Google Scholar 

  14. Frisina R, Zampedri E, Marchesoni I (2016) Lamellar macular hole in high myopic eyes with posterior staphyloma; morphological and functional characteristics. Graefes Arch Clin Exp Ophthalmol. doi:10.1007/s00417-016-3383-1

    Google Scholar 

  15. Wakabayashi T, Fujiwara M, Sakaguchi H et al (2010) Foveal microstructure and visual acuity in surgically closed macular holes: spectral-domain optical coherence tomographic analysis. Ophthalmology 117(9):1815–1824

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Multizonal Unit of Ophthalmology of Autonomous Province of Trento, corso Verona 4, 38068, Rovereto, Trento, Italy

    Elena Zampedri, Federica Romanelli & Rino Frisina

  2. Department of Ophthalmology of University of Brescia, Brescia, BS, Italy

    Francesco Semeraro

  3. Department of Ophthalmology of Sant’Anna Institute, Brescia, BS, Italy

    Barbara Parolini

Authors
  1. Elena Zampedri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Federica Romanelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Francesco Semeraro
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Barbara Parolini
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rino Frisina
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Elena Zampedri.

Ethics declarations

Funding

No funding was received for this research.

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Formal consent

For this type of study, formal consent is not required.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zampedri, E., Romanelli, F., Semeraro, F. et al. Spectral-domain optical coherence tomography findings in idiopathic lamellar macular hole. Graefes Arch Clin Exp Ophthalmol 255, 699–707 (2017). https://doi.org/10.1007/s00417-016-3545-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-016-3545-1

Keywords

Search

Navigation