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Outcomes of photorefractive keratectomy instead of phototherapeutic keratectomy for patients with granular corneal dystrophy type 2



The purpose of this study was to evaluate visual function and postoperative refractive errors in patients with granular corneal dystrophy type 2 (GCD2) and cataracts who underwent photorefractive keratectomy (PRK) instead of phototherapeutic keratectomy (PTK) following cataract surgery to avoid PTK-induced central island formation and reduce refractive errors after cataract surgery.


The medical records of 14 eyes from nine patients (one man and eight women; mean age, 69.0 ± 8.5 years) with GCD2 and cataracts were evaluated. All patients underwent PTK using the PRK mode 3 months after cataract surgery. We analyzed corrected distance visual acuity (CDVA), refractive errors, and corneal astigmatism derived from Fourier analysis and assessed the incidence of complications in cataract surgery and PTK.


The mean CDVA logMAR values were 0.42 ± 0.19, 0.38 ± 0.18, and 0.16 ± 0.12 before and after cataract surgery and after PTK, respectively. CDVA improved significantly after PTK, as compared with both before and after cataract surgery (P < 0.001). The mean absolute errors after cataract surgery and PTK were 0.53 ± 0.43 and 1.61 ± 1.01 diopters, respectively. Pre- and postoperative Fourier indices did not significantly vary in the 3-mm diameter zone, and only the asymmetry component of the 6-mm diameter zone significantly (P <0.01) increased postoperatively. No central island formation and no other marked complications were observed postoperatively in any case.


Performing PTK using the PRK mode following cataract surgery may be effective for patients with GCD2 and cataracts.

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Correspondence to Takeshi Soma.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

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Informed consent was obtained from all individual participants included in the study.

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Oya, F., Soma, T., Oie, Y. et al. Outcomes of photorefractive keratectomy instead of phototherapeutic keratectomy for patients with granular corneal dystrophy type 2. Graefes Arch Clin Exp Ophthalmol 254, 1999–2004 (2016).

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  • Granular corneal dystrophy type 2
  • Avellino corneal dystrophy
  • Cataract
  • Phototherapeutic keratectomy
  • Photorefractive keratectomy