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Internal limiting membrane transplantation for unclosed and large macular holes

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Background

To present the surgical technique and clinical outcomes of transplantation of autologous internal limiting membrane (ILM) for large macular holes (MHs) after failed surgeries with ILM removal.

Methods

Thirteen eyes of 13 consecutive patients with MHs larger than 500 μm after failed surgeries with ILM removal underwent vitrectomy with transplantation of autologous ILM. In the ILM transplantation technique, a small piece of the ILM was peeled off and transplanted inside the macular hole. Fluid–air exchange was then performed. The air was then replaced with 10 % perfluoropropane (C3F8) gas. Comprehensive ophthalmologic examinations and spectral-domain optical coherence tomography were performed preoperatively and postoperatively. The main outcome measures were best-corrected Snellen visual acuity (BCVA) and MH closure rate.

Results

The preoperative mean base diameter of the MHs was 1637.6 + 412.7 μm (range, 814–2092 μm). The preoperative mean minimum diameter was 814.4 + 255.0 μm (range, 546 μm–1485 μm). Complete MH sealing was achieved in 12 eyes after transplantation of the ILM flap. The mean BCVA was 1.15 + 0.21 (range, 1.0–1.6) before surgery and 0.99 + 0.17 (range, 0.7–1.3) at 12 months postoperatively. There was a significant difference in BCVA before versus after the surgery (t = 3.825, P = 0.0002, paired t- test).

Conclusions

Transplantation of autologous ILM is an effective addition to the surgical options for large macular holes after failed surgeries with ILM removal.

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Authors and Affiliations

  1. Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Road, DongCheng District, Beijing, 100730, China

    Yining Dai, Fangtian Dong, Xiao Zhang & Zhikun Yang

  2. Shanxi Eye Hospital, Taiyuan, Shanxi, China

    Yining Dai

Authors
  1. Yining Dai
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  2. Fangtian Dong
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  3. Xiao Zhang
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  4. Zhikun Yang
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Corresponding author

Correspondence to Fangtian Dong.

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Funding

No funding was received for this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Dai, Y., Dong, F., Zhang, X. et al. Internal limiting membrane transplantation for unclosed and large macular holes. Graefes Arch Clin Exp Ophthalmol 254, 2095–2099 (2016). https://doi.org/10.1007/s00417-016-3461-4

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  • DOI: https://doi.org/10.1007/s00417-016-3461-4

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