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Plasma E-selectin levels can play a role in the development of diabetic retinopathy

  • Retinal Disorders
  • Published:
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Abstract

Purpose

Diabetic retinopathy is one of the leading causes of blindness. There are several risk factors, such as the duration of diabetes or glycemic control of the patient; however, several biochemical factors also alter the process. Our aim was to investigate the role of soluble E-selectin in the formation of diabetic retinopathy.

Patients and methods

Fifty-seven patients (37 female and 20 male, aged 61.71 ± 12.31 years) and 14 healthy control subjects (ten female and four male, aged 63.06 ± 10.46 years) were enrolled in the study. We measured the soluble E-selectin level in the plasma of patients by ELISA. All patients underwent careful ophthalmological examination, including ophthalmoscopy and color fundus photography, while diabetic retinopathy grading was performed in line with the 2012 classification of the American Academy of Ophthalmology (AAO).

Results

The soluble E-selectin level was significantly higher in patients with diabetes compared to controls (32.95 ng/ml vs. 26.55 ng/ml, p = 0.03). Dividing patients into groups by the presence of retinopathy, the E-selectin level was also significantly higher in the retinopathy group (p < 0.05). When we examined diabetic patients by the severity of retinopathy (groups A, B, and C, by the guidelines of the AAO), however, we did not find any significant difference in soluble E-selectin levels, although it tended to be higher in group B.

Conclusions

An elevated E-selectin level can play a role in the development of diabetic retinopathy, but it does not seem to alter disease severity. However, glycemic control and the reduction of cardiovascular risk factors may also alter the level of E-selectin that might play a role in the prevention of diabetic retinopathy.

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Author information

Authors and Affiliations

  1. Medical Centre, Hungarian Defence Forces, 1134, Budapest, Róbert Károly krt. 44, Hungary

    Márta Kasza

  2. Jósa András Hospital, Nyíregyháza, Hungary

    J. Meleg

  3. Kenézy Gyula Hospital, Debrecen, Hungary

    J. Vardai

  4. Department of Laboratory Medicine, University of Debrecen, Debrecen, Hungary

    B. Nagy Jr.

  5. Department of Ophthalmology, University of Debrecen, Debrecen, Hungary

    E. Szalai, J. Damjanovich, A. Csutak, B. Ujhelyi & V. Nagy

Authors
  1. Márta Kasza
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  2. J. Meleg
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  3. J. Vardai
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  4. B. Nagy Jr.
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Correspondence to Márta Kasza.

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No funding was received for this research.

Conflict of interest

All authors certify that they have no affiliations with, nor involvement in, any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership or other equity interest; and expert testimony or patent-licensing arrangements), nor any financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

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Informed consent was obtained from all individual participants included in the study. Additional informed consent was obtained from all individual participants for whom identifying information is included in this article.

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Kasza, M., Meleg, J., Vardai, J. et al. Plasma E-selectin levels can play a role in the development of diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 255, 25–30 (2017). https://doi.org/10.1007/s00417-016-3411-1

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  • DOI: https://doi.org/10.1007/s00417-016-3411-1

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