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Circadian disturbance and idiopathic central serous chorioretinopathy

  • Retinal Disorders
  • Published:
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Abstract

Background

This present retrospective case control study was designed to evaluate circadian disturbance in patients with chronic idiopathic central serous chorioretinopathy (ICSC).

Methods

Between January 1st, 2012, and November 30th, 2014, 29 consecutive patients with chronic ICSC examined in a referral setting were compared with a gender-matched and age-matched control group of 29 patients. A history of pharmacologic medication (including corticosteroid treatment), sleep disturbance, irregular working hours, cardiovascular risk factors, and depressive anxiety disorders was noted.

Results

The median age of the patients was 52, and in the control subjects it was 50. The male–female ratio for both groups was 4.8:1. Patients with chronic ISCS were more likely to be exposed to irregular working hours (p < 0.01, OR 9.3 [2.29–37.6]) and to present with overweight than the control subjects (p = 0.016). No significant differences were found for sleeping disturbances, pharmacological medication, cardiovascular risk factors, or depressive anxiety disorders.

Conclusions

In this preliminary study, the exposition of irregular working hours as a risk factor for chronic ICSC was identified, which had not been previously reported. If further studies confirm these findings, then employment with regular working hours could be recommended for chronic ICSC patients.

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Authors and Affiliations

  1. Service d’Ophtalmologie, Pôle tête et cou, Hôpital Robert Debré, Centre Hospitalo-Universitaire, 51092, Reims, France

    Elodie Setrouk, Beatrice Hubault, Olivia Zambrowski, Alain Ducasse & Carl Arndt

  2. Centre d’évaluation et de traitement de la Douleur, Pôle d’Anesthésie-Réanimation, Centre Hospitalo-Universitaire, 51092, Reims, France

    Frédérique Vankemmel

  3. Service d’Endocrinologie, Maladies Métaboliques et de Médecine Interne, Pôle Digestif / Urologie / Néphrologie / Endocrinologie (D.U.N.E.), Centre Hospitalo-Universitaire, 51092, Reims, France

    Brigitte Delemer

  4. Pôle Thoracique / Cardiaque / Vasculaire, Centre Hospitalo-Universitaire, 51092, Reims, France

    Pierre Nazeyrollas, Brigitte Delemer & Vincent Durlach

Authors
  1. Elodie Setrouk
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  2. Beatrice Hubault
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  3. Frédérique Vankemmel
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  4. Olivia Zambrowski
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  6. Brigitte Delemer
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  7. Vincent Durlach
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  8. Alain Ducasse
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  9. Carl Arndt
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Corresponding author

Correspondence to Carl Arndt.

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Funding

No funding was received for this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria, educational grants, participation in speakers’ bureaus, membership, employment, consultancies, stock ownership, or other equity interest, and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

For this retrospective study, although formal consent is not required, informed consent was obtained from all individual participants included in the study.

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Setrouk, E., Hubault, B., Vankemmel, F. et al. Circadian disturbance and idiopathic central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 254, 2175–2181 (2016). https://doi.org/10.1007/s00417-016-3378-y

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  • DOI: https://doi.org/10.1007/s00417-016-3378-y

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