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Lamellar macular hole in high myopic eyes with posterior staphyloma: morphological and functional characteristics

Graefe's Archive for Clinical and Experimental Ophthalmology volume 254, pages 2141–2150 (2016)Cite this article

An Erratum to this article was published on 12 May 2016

Abstract

Purpose

To study morphological and functional characteristics of myopic lamellar macular hole (LMH) with posterior staphyloma.

Methods

Retrospective observational longitudinal study. Forty myopic eyes affected by LMH and posterior staphyloma have been examined. Pathological myopia was defined as axial length equal or superior to 26.5 mm. LMH was defined on the basis of the following characteristics: irregular foveal contour, inner retinal defect with or without intraretinal splitting and absence of full thickness retinal defect. Demographic and functional parameters were: age, sex, status of lens and best corrected visual acuity (BCVA). Tomographic parameters were: type of LMH, macular retinoschisis (MRS), posterior vitreous detachment (PVD), type of epiretinal membrane (ERM), integrity of ellipsoid zone (EZ) and external limiting membrane (ELM), residual foveal thickness (RFT) and maximal diameter of intraretinal splitting (MDIRS).

Results

The statistical analysis showed a significant prevalence of posterior vitreous adherence in the atypical ERM subgroup (P = 0.001). EZ (P = 0.006) and ELM (P = 0.007) damages were significantly associated with the atypical ERM subgroup. RFT was statistically lower in the atypical ERM subgroup compared to the conventional ERM subgroup (P = 0.015). During the follow-up, the statistical analysis showed a significant reduction of RFT in the atypical ERM subgroup (P = 0.041).

Conclusions

Myopic lamellar macular hole (LMH) associated with atypical ERM is a more severe clinical entity than myopic LMH associated with conventional ERM.

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References

  1. Witkin AJ, Ko TH, Fujimoto JG, Schuman JS, Baumal CR, Rogers AH, Reichel E, Duker J (2006) Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study. Ophthalmology 113(3):388–397

    Article  PubMed  PubMed Central  Google Scholar 

  2. Reibaldi M, Parravano M, Varano M, Longo A, Avitabile T, Uva MG, Zagari M, Toro M, Boscia F, Boccassini B, Chiaravalloti A, Mariotti C, Reibaldi A (2012) Foveal microstructure and functional parameters in lamellar macular hole. Am J Ophthalmol 154(6):974–980.e1

    Article  PubMed  Google Scholar 

  3. Bottoni F, Deiro AP, Giani A et al (2013) The natural history of lamellar macular holes: a spectral domain optical coherence tomography study. Graefes Arch Clin Exp Ophthalmol 251:467–475

    Article  PubMed  Google Scholar 

  4. Pang CE, Spaide RF, Freund KB (2015) Comparing functional and morphologic characteristics of lamellar macular holes with and without lamellar hole-associated epiretinal proliferation. Retina 35(4):720–726

    Article  PubMed  Google Scholar 

  5. Parolini B, Schumann RG, Cereda MG, Haritoglou C, Pertile G (2011) Lamellar macular hole: a clinicopathologic correlation of surgically excised epiretinal membranes. Invest Ophthalmol Vis Sci 52(12):9074–9083

    Article  PubMed  Google Scholar 

  6. Pang CE, Spaide RF, Freund KB (2014) Epiretinal proliferation seen in association with lamellar macular holes: a distinct clinical entity. Retina 34(8):1513–1523

    Article  PubMed  Google Scholar 

  7. Schumann RG, Compera D, Schaumberger MM, Wolf A, Fazekas C, Mayer WJ, Kamppik A, Haritoglou C (2105) Epiretinal membrane characteristics correlate with photoreceptor layer defects in lamellar macular holes and macular pseudoholes. Retina 35:727–735

    Article  Google Scholar 

  8. Compera D, Entchev E, Haritoglou C, Scheler R, Mayer WJ, Wolf A, Kampik A, Schumann RG (2015) Lamellar hole-associated epiretinal proliferation in comparison to epiretinal membranes of macular pseudoholes. Am J Ophthalmol 160(2):373–384

    Article  PubMed  Google Scholar 

  9. Duker JS, Waheed NK, Goldman DR (2014) Myopic macular schisis in: handbook of retinal OCT: optical coherence tomography. Saunders Elsevier Inc, Philadelphia, pp 50–51

    Google Scholar 

  10. Tanaka Y, Shimada N, Moriyama M, Hayashi K, Yoshida T, Tokoro T, Ohno-Matsui K (2011) Natural history of lamellar macular holes in highly myopic eyes. Am J Ophthalmol 152(1):96–99

    Article  PubMed  Google Scholar 

  11. Morgan I, Rose K (2005) How genetic is school myopia? Prog Retin Eye Res 24:1–38

    Article  PubMed  Google Scholar 

  12. Pan CW, Ramamurthy D, Saw SM (2012) Worldwide prevalence and risk factors for myopia. Ophthalmic Physiol Opt 32:3–16

    Article  PubMed  Google Scholar 

  13. Spaide RF, Ohno-Matsui K, Yannuzzi LA (2013) Pathologic myopia. Springer, New York, pp 177–185

    Google Scholar 

  14. Panozzo G, Mercanti A (2004) Optical coherence tomography findings in myopic traction maculopathy. Arch Ophthalmol 122(10):1455–1460

    Article  PubMed  Google Scholar 

  15. Takano M, Kishi S (1999) Foveal retinoschisis and retinal detachment in severely myopic eyes with posterior staphyloma. Am J Ophthalmol 128(4):472–476

    CAS  Article  PubMed  Google Scholar 

  16. Baba T, Ohno Matsui K, Futagami S, Yoshida T, Yasuzumi K, Kojima A, Tokoro T, Mochizuki M (2003) Prevalence and characteristics of foveal retinal detachment without macular hole in high myopia. Am J Ophthalmol 135(3):338–342

    Article  PubMed  Google Scholar 

  17. Ikuno Y, Sayanagi K, Ohji M, Kamei M, Gomi F, Harino S, Fujikado T, Tano Y (2004) Vitrectomy and internal limiting membrane peeling for myopic foveoschisis. Am J Ophthalmol 137(4):719–724

    PubMed  Google Scholar 

  18. Gaucher D, Haouchine B, Tadayoni R, Massin P, Erginay A, Benhamou N, Gaudric A (2007) Long-term follow-up of high myopic foveoschisis: natural course and surgical outcome. Am J Ophthalmol 143(3):455–462

    Article  PubMed  Google Scholar 

  19. Benhamou N, Massin P, Haouchine B, Erginary A, Gaudric A (2002) Macular retinoschisis in highly myopic eyes. Am J Ophthalmol 133(6):794–800

    Article  PubMed  Google Scholar 

  20. Shimada N, Ohno-Matsui K, Baba T, Futagami S, Tokoro T, Mochizuki M (2006) Natural course of macular retinoschisis in highly myopic eyes without macular hole or retinal detachment. Am J Ophthalmol 142(3):497–500

    Article  PubMed  Google Scholar 

  21. Sun CB, Liu Z, Xue AQ, Yao K (2010) Natural evolution from macular retinoschisis to full-thickness macular hole in highly myopic eyes. Eye (Lond) 24(12):1787–1791

    CAS  Article  Google Scholar 

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Affiliations

  1. Multizonal Unit of Ophthalmology of Autonomous Province of Trento (TN), Square Santa Maria n. 6, 38068, Rovereto, Trento, Italy

    Frisina Rino, Zampedri Elena, Marchesoni Ivan, Bosio Paolo & Romanelli Federica

  2. Department of Ophthalmology of Sant’Anna Institute, Brescia, BS, Italy

    Parolini Barbara

Authors
  1. Frisina Rino
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  2. Zampedri Elena
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  3. Marchesoni Ivan
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  4. Bosio Paolo
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  5. Parolini Barbara
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  6. Romanelli Federica
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Correspondence to Frisina Rino.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s00417-016-3383-1.

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Rino, F., Elena, Z., Ivan, M. et al. Lamellar macular hole in high myopic eyes with posterior staphyloma: morphological and functional characteristics. Graefes Arch Clin Exp Ophthalmol 254, 2141–2150 (2016). https://doi.org/10.1007/s00417-016-3371-5

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  • DOI: https://doi.org/10.1007/s00417-016-3371-5

Keywords

  • Lamellar macular hole
  • Epiretinal membrane
  • Macular retinoschisis
  • Posterior vitreous detachment
  • Myopic traction maculopathy
  • Ellipsoid zone